Scientist – Process Development (Downstream)

Date Posted: 8/20/2018 Reference: VAC-1189918 Salary: £0 Location: Oxford Job type: Permanent Sector: Science | Speciality: Pharmaceuticals Contact: Kieran Whittaker

The Client

My client, a leader in synthetic biology, is a specialised contract research organisation offering services to support the discovery, development and production of biologics, with a particular focus on viral vectors for gene therapy applications.

A unifying theme across the portfolio is expertise in DNA design, expression system optimisation, cell line development and engineering of viral delivery systems.

They are located within purpose-fitted laboratories at the Oxford Science Park, just South of Oxford.

They are in a phase of rapid expansion and are seeking highly motivated and enthusiastic scientists and engineers to join the team and help facilitate the next stage of their development as a company.

My client aims to be both innovative and entrepreneurial in everything they do – Will you join them and contribute to this exciting journey?

The Role

You will be involved in a range of internal platform development and commercial projects, focusing on establishing process development capabilities for the production of both therapeutic proteins and viral vectors for gene therapy applications. My client has a number of on-going programmes in this area, and multiple government supported grant awards, which the recipient will contribute towards.

The Process Development Scientist (Downstream) will work together with Scientist colleagues to specify and implement scalable processes for primary recovery and product purification. The position will involve extensive interaction with both internal and external stakeholders, and the ability to show commitment to scientific development and innovation are considered essential.

Prior experiencing of using relevant techniques, including TFF, ultracentrfugation and AKTA-based chromatography (Affinity, IEX and SEC) is absolutely required, as is experience in developing and implementing associated process for mammalian production systems. The position will work closely with the Cell Line Development, Upstream Process and Analytical teams, and will report to the Chief Technology Officer.


• Lead, plan and conduct primary recovery and purification experiments including use of statistical approaches for process design and specification (DOE, QbD)
• To support technology transfer activities for commercial manufacturing
• To work closely with internal and external stakeholders to define project goals and deliverables, in line with planned project objectives
• To keep up to date with the scientific literature and developments in the field
• Set an example to other colleagues, and to train and mentor junior staff
• Perform data analysis, author Standard Operating Procedures and write technical reports
• Support and contribute to protection and assessment of intellectual property
• Promote and suggest implementation of new methods, technologies and processes to ensure best practice
• To ensure established quality standards are strictly adhered to, across all on-going activities

Salary is negotiable on experience


For more information and a confidential discussion, please contact Kieran Whittaker on the below: -

Tel: 0161 923 8174