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We found 257 job(s) for you:

  • Senior / Principal / Lead MSAT Scientist. Contract

    Salary: £0 Location: Oxford

    Senior/Principal /Technical Lead Scientist/Engineer (MSAT). Contract. Oxford My client, a globally renowned Gene Therapy are under going a phase of expansion. As part of this, they require support in Manufacturing Sciences and Technology team. There are currently 3 open positions for Contract MSAT Scientists/Engineers. Company and Team Overview An exceptional company with over 20 years’ experience in Gene and Cell therapy. True pioneers in the field, they were the first organisation to treat humans through in vivo lentiviral based vectors. This MSAT team is involved in all aspects of clinical and commercial manufacturing carried out either in-house or by third party CMO’s on behalf of the company. Job Overview ? Provide technical and scientific leadership to clinical and commercial manufacturing on-site and third party CMO sites including technology transfer, technical troubleshooting, complex deviation investigations, change control, and continuous improvement. ? Perform root cause investigations using a systematic approach to resolve complex problems and lead multidisciplinary teams in developing and implementing solutions. ? Gather, evaluate and analyse complex process data for all products and sites for manufacturing process robustness and capability via ongoing process verification. ? Partnering with other functions to ensure scale-up is robust and scientifically sound leading to consistent performance Key Responsibilities and Accountabilities ? The successful candidate will be an influential MSAT representative within the organisation working across multiple projects at different stages of the commercial lifecycle. ? Lead cross-functional activities working across Research, Process R&D, Manufacturing, Supply Chain and Quality Groups. ? Technical reviewer of manufacturing documentation (batch manufacturing records, deviation handling, CAPA, change controls, SOPs, etc.) ? Responsible for internal documentation to ensure quality and compliance required for regulatory submissions. ? Generate and review documentation supporting technology transfer and NPI. Define success criteria for technical transfer and provide expert evaluation of the technical outcomes. ? Help to build and maintain a process-specific knowledge database for technology transfer, NPI and process stewardship; identify continuous improvement activities to improve performance. ? Develop relationships with suppliers and service providers ? Provide guidance on process transfer and support activities to junior members of the team. Key Skills and Requirements ? Process development or GMP production experience preferred. ? Experience in aseptic processing and/or fill & finish would be an advantage. ? Proven influencing skills at all levels of the company across multiple project teams. ? As a person in plant, provide technical support and training of manufacturing personnel to improve understanding of cell culture, purification and fill & finish operations across the manufacturing sites. ? Expertise in the use / application of variety of problem solving tools and quality risk assessment methodologies would be ideal. *Travel may be required in support of tech transfer activities. Person Specification ? Minimum post-graduate degree in Biology/Biochemistry, Chemical/Biochemical Engineering or a related field with a minimum of 5+ years of industrial experience. ? Alternatively, a candidate with extensive industrial experience in Biologics (7 years+), ideally within a GMP regulated environment. ? Demonstrated interpersonal skills with ability to work cross-functionally both with internal and external partners. ? Excellent communication skills to gain internal company support and influence external CMOs at all levels. ? Good time management and experience of dealing with conflicting priorities and multiple tasks. ? An interest in operational excellence is desirable. ? Knowledge of Microsoft Office Suite is required; preferably with data base development experience. ? Experience in process automation and software solutions would also be an advantage. The Package The successful candidates can expect a generous hourly rate and significant length of contract. In addition, this is an excellent opportunity to join a real player in the Gene Therapy sector and a chance to gain referrals, recommendations and build reputation.

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  • Deep Learning Researcher

    Salary: £45000 Location: Oxford

    Based in Oxford, my client are a leading medical imaging technlology company who are looking for a first-class medical imaging researcher to join their technology team, developing cutting-edge image processing and deep learning algorithms to improve acute stroke diagnosis. You will take a leading role in researching the fundamental science and algorithms that contribute to the company’s core IP. This is an exciting opportunity to bring the latest medical imaging research into real-world use. You must have an excellent understanding of state of the art medical imaging technology, with a PhD in a relevant research area, or otherwise demonstrate outstanding research ability. Recent work with contrast and non-contrast CT, or MRI image analysis would be particularly desirable, especially in brain imaging or stroke-related fields. Other skills we are looking for include: + A good core knowledge of computer vision and image processing algorithms, particularly filtering, image registration and classification techniques. + Experience with developing deep learning algorithms for image analysis + Active participation in the medical imaging research community + Programming expertise in Python + An ability to clearly communicate complex ideas and systems, both to technical colleagues (e.g. software developers) and non-technical audiences, both verbally and through graphical or textual content + An ability to generate creative ideas and solutions to real-world problems, based on a deep understanding of the problem domain + Data science skills, including data preparation, cleaning, and scripting You will be given a significant share of responsibility for the underlying technology behind my clients products, and you should be able to work independently on complex problems. However, team members are expected to work together to find elegant solutions to issues from all areas of the company, so clear communication is vital.

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  • Business Analyst

    Salary: £40000 Location: Basingstoke

    Owing to continued ambition and expansion, this global leading FinTech provider is actively recruiting for a Business Analyst. This role will be particularly suited to someone of a junior to mid-level status and seeking career progression and opportunities to learn new skills and take on board training. The Financial Technology industry’s only independent global provider of customer focused, end-to-end, data-driven cash management solutions. With an onus on developing long-term relationships with clients which add value through optimizing efficiency, protect investment and safeguard reputations. This is a team-based role reporting to an experienced Business Analyst Manager. The successful candidate will be responsible for the definition procedural, process and system requirements and documenting specifications for customer specific and roadmap projects. To design, develop, manage and test individual work packages for such projects and to work with internal teams and external suppliers. Candidates should have experience of the following; + 1-4 years experience as a business analyst ideally within a software or solutions provider. + UML + AGILE experience + Prince 2 + C#, ASP.NET Salary ranges are expected to be in the 25-40k range dependent on experience.

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  • Apex Developer / Salesforce

    Salary: £60000 Location: Paris

    Based in Paris, my client is a large-scale startup dedicated to improving the quality of life of patients, reducing healthcare costs and fighting against medical deserts. They develop innovative solutions for unmet medical needs for patients and healthcare professionals: connected clothing, data analysis algorithms and applications for diagnosis, surveillance, remote consultations. The company is already working with more than 40 hospitals and consists of about 100 people, covering multiple disciplines: medicine, textile, embedded electronics, computer science and design to name a few. Their offices are located at Station F, the largest incubator of startups in the world, and in the hospital of Pitié-Salpêtrière in Paris. They are currently looking for an experienced developer to strengthen their team. You will be able to work on the development of their tele-expertise and teleconsultation platforms dedicated to people suffering from sleep disorders or heart failure. My client choose to use reliable and proven technologies to ensure their scalability: + Front: Angular, TypeScript, CSS + Back: Java, Spring Boot, PostgreSQL, MongoDB, Kafka + Ops: AWS, PowerShell, Heroku, Ansible, Jenkins, Docker It is not essential to master the entirety of the technical stack, because you will have the chance to evolve alongside senior engineers. They are primarily looking for people who are curious and resourceful, motivated to learn and face the challenges of IoT, cloud and medical. As this sector is not very agile by nature, they aim to support their partners in this transformation. Salaries are expected to be in the €45-60k region.

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  • Scientist (Bioinformatics – Genome Editing)

    Salary: £38000 Location: Oxford

    My client, a leader in synthetic biology, is a specialised contract research organisation offering services to support the discovery, development and production of biologics, with a particular focus on viral vectors for gene therapy applications. A unifying theme across the portfolio is expertise in DNA design, expression system optimisation, cell line development and engineering of viral delivery systems. They are located within purpose-fitted laboratories at the Oxford Science Park, just South of Oxford. They are in a phase of rapid expansion and are seeking highly motivated and enthusiastic scientists and engineers to join the team and help facilitate the next stage of their development as a company. My client seeks an enthusiastic and self-starting bioinformatician to design, implement and evaluate novel software tools to support their genome editing group. In particular, the successful applicant will train machine learning models to predict the targeting patterns of CRISPR/Cas9 gRNAs. The successful applicant will join their interdisciplinary bioinformatics team, working alongside scientific programmers, infrastructure engineers, and web app developers to support both commercial and R&D projects. No prior experience of working with CRISPR/Cas9 is needed. Key Responsibilities + Work with the genome editing team and NGS specialists to develop a framework for reliably evaluating the targeting patterns of CRISPR/Cas9 gRNA libraries. + Apply state-of-the-art data science and statistical learning techniques to derive gRNA suitability/fitness rule-sets from the in-house CRISPR/Cas9 NGS datasets. + Engineer user-friendly software tools to facilitate CRISPR/Cas9 gRNA library design against new targets; work closely with the in-house software engineers to integrate interfaces for these into the web-based LIMS. + Stay up-to-date with new developments, technologies and methods in genome editing, and proactively seek out collaborations with their group leaders to develop and extend our intellectual property portfolio in this area. + Carry out any other duties commensurate with the grading of this post, as required. Salary is negotiable on experience.

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  • CMC Technical Specialist

    Salary: £60000 Location: Oxford

    CMC Technical Specialist – Oxford – Cell & Gene Therapy co. – up to £60,000 per annum The role is as an office-based technical specialist and author to provide Chemistry, Manufacturing and Controls (CMC) technical input into my client’s projects and external clients. The role includes overseeing CMC studies to ensure on-time delivery for project deadlines. In addition to liaising with my client’s staff across all operational departments, the successful applicant will also be required to build and maintain collaborative relationships with external organisations. + Collaborate with external partners to provide CMC technical support where my client’s technologies are employed. + To support and/or coordinate studies or activities for regulatory applications within defined project deadlines. + Support provision of high-quality documentation (e.g. technical protocols and reports) related to CMC sections of clinical trial applications and INDs, Marketing Authorisation Applications (MAAs) and Biological Licence Applications (BLAs). + Provide input for improvement of CMC technical development strategy, to keep it up-to-date with the evolving scientific and competitive environment. Key responsibilities: + Working closely with staff and project team members of client organisations to ensure delivery of CMC source documentation in support of regulatory submissions. + To author plans/protocols and reports and co-ordinate CMC-related studies e.g. Comparability protocols and reports. + To review CMC-related documents drafted by other departments to ensure that they meet regulatory and client expectations. To review CMC-related text incorporated into regulatory documentation to ensure accuracy and consistency with source documents. + To advise on the scope and impact of manufacturing and analytics planned changes and quality incidents. + To advise on analytical specifications to meet regulatory and client requirements, and to advise on corresponding acceptance limits. + To attend interdisciplinary project team meetings and provide updates on CMC-related activities. Key skills and requirements: + Educated to a minimum of Degree in a relevant scientific discipline, or equivalent qualifications and/or experience. + Knowledge of GMP-compliant manufacturing and/or analytics for biological medicinal product to support clinical development and commercial scale-up. + Previous experience of drafting high quality documentation such as technical reports. Desirable but not essential: + Knowledge of manufacturing and/or analytics for gene therapy vectors. + Experience of working within a CMC-focussed technical position (e.g. development, manufacturing and/or analytics) within the biopharmaceutical industry. The starting salary for this role ranges between £45,000 - £60,000 per annum, dependant on experience and qualifications.

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  • Validation Manager

    Salary: £65000 Location: OXFORD

    Validation Manager (permanent)- Oxford- Biotech- up to £65k Based in Oxfordshire, my client is a world leader in Gene and Cell Therapy technologies. Due to a fantastic period of growth they have an exciting opportunity for a motivated individual to join and lead the validation department as a Validation Manager. You will be responsible for acting as the subject matter expert and supporting the GMP manufacturing facilities by managing and coordinating all aspects of validation (equipment & facilities qualification and routine requalification activities, cleaning validation, computerised systems validation and process validation) and overseeing the Validation Team. Key skills and requirements: You will have: BSc in life sciences or another relevant subject Significant validation experience within a GMP environment Valid UK Driving License Significant team management experience. Proven problem-solving skills/diagnosing faults/resolving qualification issues. Competitive Salary Fantastic development opportunities Great Career progression

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  • 3rd Line Engineer

    Salary: £37000 Location: Wetherby

    I am currently recruiting for a reputable solutions provider based just outside of Leeds, this company has been established for over 30 years with a company portfolio of over 250 companies. The role I am recruiting for is a 3rd Line Technical Consultant, this person is pivotal to the company and will be the within a team of 4 that are the 1st point of call when it comes to projects, and the last line of defence when it comes to technical issues. **What the 3rd Line Technical Consultant will need*** + MCSE 2012 & expert level experience within the Microsoft server environment + End-to-end experience with VMware (preferably VCP level) + Solid infrastructure deployment experience + Good understanding of networking principals + Excellent with documentation and sharing best practice ***What the 3rd Line Technical Consultant will get*** + Competitive salary up to £40,000 + Excellent project pipeline + Paid training (MCSE/VCP/CCNA) + Great benefits package ***PLEASE NOTE: SC Clearance must be achieved for this post*** If this sounds like the prefect role for you then please get in touch today!

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  • Quality Associate

    Salary: £27000 Location: Oxford

    Based in Oxford my client are a leading research organisation offering services to support the discovery, development and production of biologics, with a particular focus on viral vectors for gene therapy applications. A unifying theme across the portfolio is expertise in DNA design, expression system optimisation, cell line development and engineering of viral delivery systems. They are located within purpose-fitted laboratories at the Oxford Science Park, just South of Oxford. They are currently looking for a Quality Associate with the following skills; + BSc in relevant discipline, with experience in a biological sciences laboratory environment + Experience working in a commercial / industry setting is preferred but not essential + Excellent working knowledge and skills in Microsoft Excel, Word and Outlook + High-level attention to detail, analytical and problem-solving skills + Previous experience working to ISO9001 and GLP quality standards + Previous experience in a quality assurance role. Salaries for the role are expected to be in the 20-28k range.

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  • Senior Design Engineer

    Salary: £60000 Location: Oxford

    Based in Oxford the Senior Design Engineer will be part of a cross-functional team, responsible for the CAD, prototyping and early stage process engineering for the optical module of a 3rd party Augmented Reality application. This is a customer facing role and requires excellent communication and presentation skills. During the project, the Senior Design Engineer may lead sub-project teams focussed on resolving particular design challenges. They will be responsible for managing the design process for a number of components and sub-assemblies, from specification review and concepting to prototype release; including production and testing of prototypes and development of the prototype manufacturing process flow and Design for Manufacture (DfM) activities. The role therefore requires close and efficient coordination with the process team operating the product prototyping line and liaison with third party suppliers of materials, sub-components and equipment. Candidates should have the following skills; + Must be an experienced designer / engineer, possessing excellent written and oral communication skills (10+ years) + Team leadership skills + Working in a high-tech multidisciplinary environments; experience of customer-facing engineering consultancy an advantage + Experience managing suppliers + Working in accordance to ISO 13485, MDD and FDA 21 CFR regulations preferred but not essential. Salaries are expected to be in the 60k region.

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