Biotechnology

  • Data Scientist 5/21/2019 12:00:00 AM

    Salary: £60000 Location: London

    I am currently recruiting for a ground breaking AI company in London, who are recruiting for a Data Scientist to continue their work in discovery of high-value protein components. ***What the Data Scientist will be doing*** + Establish robust workflows for processing the empirical datasets produced by our biologists + Use statistical analysis and interpretable machine learning to uncover insights from very large sequence-to-function datasets + Build deep learning architectures to predict sequence functionality + Generate sequence libraries with insights and guidance acquired from machine learning ***What the Data Scientist needs*** + 2 or more years of experience with designing and building deep neural networks, preferably in a production environment + Hold a relevant PhD in Computer Science, Mathematics, Computational Biology, Physics, Statistics, or related fields or 3+ years industry experience + Python data science ecosystem (e.g. scikit-learn, pandas, TensorFlow) + Previous work with computational biology tools and raw biological data ***What the Data Scientist will get*** + Competitive salary up to £60,000 + A support and development structure that will support you fully in your career goals + flexible working arrangements, self-service learning budget, on-site gym and climbing wall

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  • Scientist, Phage Selections 5/16/2019 12:00:00 AM

    Salary: £0 Location: Cambridge

    My client is an industry leading life sciences company dedicated to providing Life Scientists with the high quality, unique and powerful tools they need to develop safe and novel diagnostics and treatments. Currently, the company are developing novel bio-therapeutics that will compete with monoclonal antibodies and antibody mimetics in the future of diagnostics and treatments. Due to recent expansion and growth, they are looking for enthusiastic (Senior) Scientists to join their Discovery Team. Working in a state-of-the-art facility, your role will be to design and carry out phage display selections, screening and characterisation of outputs in order to identify lead therapeutic candidates. What you will need • A BSc or MSc in a biological discipline • A minimum of 2 years’ laboratory experience • A high level of lab-based competency in molecular biology, manipulating DNA and creating expression constructs. • Excellent aseptic technique and microbiology techniques • A good understanding of characterising protein-protein interactions using a variety of assays (e.g. ELISA, cell-based assays, Biacore/Octet etc.) • Experience of recombinant E.coli expression systems, protein purification and characterisation (SDS-PAGE, Western blot etc.) What you will get • State-of-the-art laboratories • Competitive Salary • Great Benefits Package This a great opportunity to be part of a dynamic team developing unique and ground-breaking bio-therapeutics. Get in touch today to ensure that you don’t miss out!

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  • Computational Biology 5/16/2019 12:00:00 AM

    Salary: £0 Location: Kidlington

    Looking for immediate interviews; Based in Oxford, my client is a market leader biotechnology. Due to a fantastic period of growth they are looking to take on a Computational Biologist, to be responsible for developing, testing and maintaining data analysis workflows, used both internally and by customers for our next-generation sequencing (NGS) products business. The role will involve designing and implementing new analytical methods for NGS data and delivering high-quality prototypes to agreed specifications and timelines for incorporation into the Computational Biology NGS software product range after rigorous testing and validation. The Data Analysis team liaises directly with customers and other stakeholders to answer any analytical questions and related support, so excellent written and verbal communication skills are essential. Additional responsibilities will include providing first line NGS data analysis support for R&D and QC teams within the company. You will have: • BSc (ideally MSc or higher) in bioinformatics or another relevant subject string in statistical, numerical, analytical or computational methods. • Good understanding of molecular biology. • Programming skills ideally in Java, Perl, Python or R. • Strong Unix skills including bash and command line tools. Competitive salary Great benefits Fantastic development opportunities

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  • Senior Stem Cell Scientist 5/15/2019 12:00:00 AM

    Salary: £0 Location: Bristol

    Bristol – Senior Stem Cell Scientist Based in the Southwest of England, my client is looking to address some of the biggest global challenges facing ethical food sourcing and environmental impact. Using cutting edge, cell culture techniques, they are looking to combine biotechnological advancements and create real meat, without harming our health, planet and animals. They are currently looking for a Senior Stem Cell Scientist, to join as part of our founding team! Your responsibilities: We’re looking for senior cell scientist excited by the challenges of creating cell-based meat! As a senior scientist you will lead the cell culture development team to create robust, scalable and low-cost protocols. You will work closely with the process development team to ensure the aforementioned. You will manage the lab including writing standard operating procedures and protocols. You will work to create novel formulations of cell culture media to significantly reduce its cost. You will also work towards creating consistent animal cell lines. It is an exciting opportunity to solve complex problems regarding cell culture! You have: • PhD in cell biology, molecular biology, biochemistry or related fields • Experience with pluripotent stem cells (iPSCs preferable) • The ability to work independently in experiment design, execution and optimization • A track record in working on complex and multidisciplinary projects Salary: (based on experience) Equity shares Fantastic development opportunities

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  • Scientist/ Senior Scientist – Assay Biology 5/15/2019 12:00:00 AM

    Salary: £0 Location: Cambridge

    My client is an industry leading life sciences company dedicated to providing Life Scientists with the high quality, unique and powerful tools they need to develop safe and novel diagnostics and treatments. Currently, the company are developing novel bio-therapeutics that will compete with monoclonal antibodies and antibody mimetics in the future of diagnostics and treatments. Due to recent expansion and growth, they are looking for a for an enthusiastic and highly skilled Scientist or Senior Scientist, depending on experience, to join their dynamic team. Working in a state-of-the-art facility, the successful candidate will set up and develop a range of cell based/binding assays to support the screening of potential therapeutic candidates. You will also be characterising lead molecules for biological functionality and supporting the company’s pre-clinical assay development/cell biology needs. What you will need • A BSc/PhD or equivalent in a biological discipline • Previous industrial experience with a focus on immunology, oncology or drug development • Be able to demonstrate a strong ability to develop target binding (e.g. ELISA, HTRF, BIAcor) and phenotypic based assays (phosphorylation, cell proliferation etc) using a range of techniques (e.g. Western blot, flow cytometry, confocal microscopy and IHC) • Experience in primary cell culture to set up functional assays What you will get • State-of-the-art laboratories • Competitive Salary • Great Benefits Package This a great opportunity to be part of a dynamic team developing unique and ground-breaking bio-therapeutics. Get in touch today to ensure that you don’t miss out!

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  • Research Scientist 5/15/2019 12:00:00 AM

    Salary: £0 Location: Saffron walden

    Research Scientist– Biopharmaceutical - Cambridgeshire Based in Cambridge, my client is a specialist biopharmaceutical company, focusing on diagnosis and treatment of a wide range of diseases, including infections, autoimmune disorders and cancer. Due to a fantastic period of growth they are looking to take on an experienced Research Scientist with in their Pre-Clinical development team. You will be responsible for the characterisation of novel anaerobic bacteria, as well as the development of a variety of disease specific assays to functionally screen the bacteria in vitro and determine suitability for therapeutic use. The role with provide the opportunity to collaborate with a variety of scientists from different disciplines both internally and externally. Key duties will include: •Developing microbiological and molecular assays to characterise novel bacterial isolates •Developing high throughput bacterial functional screening assays to assess strain efficacy in vitro •Characterisation of novel bacterial isolates to assess their suitability as Live Bacterial Therapeutics •Supporting other departments by contributing expertise in bacterial physiology You will have: •PhD in Microbiology or another related discipline •Practical experience in bacterial physiology •Proven ability to develop high throughput screening assays •An ability to design, execute and document experimental activities to a high standard •An ability to work independently and as part of a team, within a multidisciplinary environment. Desirable requirements for this post include: •Experience working with anaerobic bacteria •Industrial experience in analytical method development and validation in a drug development environment •Experience studying bacteria-host interactions Competitive Salary Great benefits Fantastic career development opportunities

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  • Soft Services Manager - Biotech 5/15/2019 12:00:00 AM

    Salary: £35000 Location: Stevenage

    Soft Services Manager • State of the art Biotech facility • Greenfield project • Develop and maintain customer relationships • Broad ranging role • Scope to make a difference A rare opportunity to play a new role at a purpose-built Biotech facility in Stevenage, using your experience and knowledge of first-class soft service provision to design, lead and inspire the whole of the soft services function. As an experienced soft services professional youll likely be able to demonstrate: • Vendor and supplier management • Contract costing • Service quality innovation and continuous improvement • Budget control • Internal and external reporting and review • SLA actions planning • People resource managing This is a highly cross-functional role so your stakeholder engagement, customer services and team-leading skills will be really useful. The site is a Biopharmaceutical production facility so it would tremendously useful if you have previous experience in Pharmaceuticals, or at least a regulated environment. Experience of COSHH for example would be really beneficial. The role will involve supervision of Front of House, Security Housekeeping and Catering. The security element means youd need to be SIA licenced. The company is on a fast growth curve and this role will provide opportunity for progress. Its the kind of site where you can really make a difference, so if youve been looking for a place to make your mark, here’s a great opportunity. Starting salary is up to £35k with a range of leading benefits. Get in touch today if this sounds like the sort of challenge you’d enjoy.

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  • Data Engineer 5/14/2019 12:00:00 AM

    Salary: £0 Location: Oxford

    Based in Oxford my client is a specialist AI driven company focused on combining technology and ethically sourced patient data, to increase patient wellbeing. Having two sides to this business, they aim to build digital health products & systems to help provide early detection as well as providing self-management help for patients. They then have a collaborative partnership with the NHS, whereby they provide my client with anonymised patient data so they can use this for research purposes. They are building AI into these databases to be able to answer questions for large pharmaceutical companies, so that they can improve drugs and discover new medicines based on real patient data. The Role: As a Data Engineer, you will be responsible for building and optimising their data architecture and pipelines, as well as data flow and data collection for cross functional teams. You’ll be supporting their Digital Health and Clinical AI research teams carrying out data sourcing, data wrangling and feature engineering tasks. Responsibilities: + Create and maintain an optimal data pipeline architecture and data warehousing in a greenfield environment. + Identify, design, and implement internal process improvements: automating manual processes, optimising data delivery, re-designing infrastructure for greater scalability, etc. + Build the infrastructure required for optimal extraction, transformation, and loading of data from a wide variety of data sources using big data technologies. + Work to deliver configurable, scalable, reliable tools in the form of infrastructure-as-code solutions. Requirements: + Qualified to BSc level in Computer Science, Software Engineering or other relevant quantitative discipline, or equivalent. + Extensive practical knowledge of multiple database architectures (SQL, noSQL, graph databases). + Experience architecting and optimising ‘big data’ data pipelines and warehousing / data lakes with leading edge tooling (e.g. the Hadoop/Apache ecosystem, data warehousing technologies, etc). + A successful history of manipulating, processing and extracting value from large disconnected datasets for the purposes of creating datasets that mean functional / non-functional business requirements. + Experience with data pipeline and workflow management tools such as Azkaban, Luigi, Airflow, etc. + Experience with at least one of the major cloud services (Google / AWS / Azure) and their associated data technologies (e.g. EMR/RDS/Redshift for AWS), OpenStack experience a strong plus. +Strong knowledge of at least one major programming language (Python, Java, Scala, etc).

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  • Data Engineering Lead 5/14/2019 12:00:00 AM

    Salary: £0 Location: Oxford

    Based in Oxford my client is a specialist AI driven company focused on combining technology and ethically sourced patient data, to increase patient wellbeing. Having two sides to this business, they aim to build digital health products & systems to help provide early detection as well as providing self-management help for patients. They then have a collaborative partnership with the NHS, whereby they provide my client with anonymised patient data so they can use this for research purposes. They are building AI into these databases to be able to answer questions for large pharmaceutical companies, so that they can improve drugs and discover new medicines based on real patient data. The Role: As a lead on my clients Data Engineering and Analytics team, you will be responsible for building and leading a team of data engineers who will build and support their data architecture. You will be interfacing with teams across the business, including their Analytics, Digital Health and Clinical AI research teams, to deliver consistent and scalable access to clean data wherever it is required. You will also be responsible for leading and managing the interface to my client’s external data partners, including NHS Trusts. Responsibilities: + Reporting to the CTO, build and lead a team of data engineers to deliver on business requirement for the flow and processing of data, as well as building a team culture that fosters innovation and quality. + Create and maintain an optimal data pipeline architecture and data warehousing in a greenfield environment. + Identify, design, and implement internal process improvements: automating manual processes, optimising data delivery, re-designing infrastructure for greater scalability, etc. + Design the infrastructure required for optimal extraction, transformation, and loading of data from a wide variety of data sources using big data technologies. + Work with stakeholders to assist with data-related technical issues and support their data infrastructure needs, as well as advising the business as required on strategic issues related to data engineering. Requirements: + Qualified to BSc level in Computer Science, Software Engineering or other relevant quantitative discipline, or equivalent. + Minimum of three years’ experience working in data engineering roles and demonstrated experience leading teams. + Extensive technical knowledge of data engineering tools, techniques, and processes as well as demonstrated delivery of data warehousing and pipeline projects. + Demonstrated ability to interface successfully with stakeholders, including technical colleagues such as machine learning teams, to deliver value on big data sets. + A successful history of manipulating, processing and extracting value from large disconnected datasets for the purposes of creating datasets that mean functional / non-functional business requirements. + Strong knowledge of at least one major programming language (Python, Java, Scala, etc). For more information regarding this opportunity, contact Robert Frame on 0161 923 8189 or orbert.frame@wearenorthpoint.com

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  • Senior Protein Scientist 5/13/2019 12:00:00 AM

    Salary: £50000 Location: Cambridge

    Based in Cambridge my client is a market leader in the next generation of biotherapeutics. Due to continued growth they are looking for highly motivated Senior Protein Scientist, who will work within a team to biophysically characterise lead antibodies, carry out formulation and stability studies, develop and transfer QC assays and manage projects with CRO’s You will be responsible for: + Clone, express, purify and characterise lead monomers and formatted proteins for characterisation and stability testing, using a range of different expression platforms (bacterial or mammalian cells). + Carry out optimisation studies to increase production yields using fermenters or shake flasks to transfer for scale up. + Develop protein purification protocols using conventional chromatography resins to purify gram quantities of proteins in-house. + Develop QC analytic assays for characterising lead proteins (e.g. using HPLC and SPR). + Develop analytical HPLC based assays (e.g. size exclusion, reverse phase chromatography, IEX) to characterise batch-to-batch variation of in-house produced lead antibodies. + Carry out accelerated stability studies on lead molecules to characterise changes that may occur at the amino acid level (e.g. oxidation, deamidation etc). + Present work/data at internal group/company meetings when necessary and produce accurate scientific reports. + Support the Tech transfer of assays developed in-house to external CROs. + Train other members of staff key techniques when required and author/approve protocols and Project manage collaborations or internal programs and have knowledge of the target biology. You will have: • An MSc/PhD or equivalent in protein biochemistry, protein engineering or molecular biology. • Experience of working with Standard protein production techniques and protein engineering knowledge, including working with a range of protein expression platforms (e.g. bacterial and mammalian). • Practical knowledge of the AKTA purification platform, Unicorn software and using conventional chromatography resins e.g. HIC, ion exchange, multimodal etc, to build multistage protein purification processes to achieve high recovery and purity yields of product. • Experience with developing a wide range of analytical HPLC based assays for protein characterisation. • Excellent knowledge of a range of methodologies to characterise proteins (e.g. SPR, ELISA, SDS-PAGE, Western blot). Competitive salary (dependent on experience) Great development opportunities

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