Biotechnology

  • Assay Development Scientist 3/22/2019 12:00:00 AM

    Salary: £0 Location: Wetherby

    My client is an industry leading life sciences company dedicated to providing Life Scientists with the high quality, unique and powerful tools they need to develop safe and novel diagnostics and treatments. Currently, the company are developing novel bio-therapeutics that will compete with monoclonal antibodies and antibody mimetics in the future of diagnostics and treatments. Due to recent expansion and growth, they are looking for a for an enthusiastic and highly skilled Assay Development Scientist with previous experience in assay development using antibodies, antibody fragments or non-antibody scaffold technologies in either the CRO or biotech sector. Working in a state-of-the-art facility, the role will be to setup and develop a range of in vitro assays (such as ELISA, cell-binding assays etc.) to support protein characterisation and the validation of their technology in industry-standard assays. What you will need • One of the following: o A BSc in a biological discipline with at least 5 years industry experience o A PhD in a biological discipline with at least 2 years industry experience • Industrial laboratory experience should be of working with and developing assays using antibodies, fragments and/or non-antibody scaffold technologies. • Be able to demonstrate a strong ability to develop target binding (e.g. ELISA, LFD, Agglutination) and phenotypic based assays (phosphorylation, cell proliferation etc.) using a range of techniques (e.g. Western blot, flow cytometry, confocal microscopy and IHC). • A bold and innovative nature and a desire to be fully involved in driving the growth of the business What you will get • State-of-the-art laboratories • Competitive Salary • Great Benefits Package This a great opportunity to be part of a dynamic team developing unique and ground-breaking bio-therapeutics. Get in touch today to ensure that you don’t miss out!

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  • Computational Biologist 3/21/2019 12:00:00 AM

    Salary: £0 Location: Oxford

    I am currently recruiting for a company based in Oxford, and they are looking for a Computational Biologist with a flair for AI/ML. Having two sides to this business, they have the product side which builds digital health products / systems to help provide early detection / provide self-management help for patients. Then they have the other side, where the NHS provides them with anonymised patient data so they can use this for research purposes. They are building AI into these databases to be able to answer questions for large pharmaceutical companies, so that they can improve drugs and discover new medicines based on real patient data. ***What the Computational Biologist will do*** I am looking for a highly-motivated Senior Data Scientist/Bioinformatician to lead projects that will develop and deliver cutting edge therapies and biomarkers to benefit patients + The ideal candidate must demonstrate proven experience in leading independent research projects at the interface between biology, informatics, genetics and/or medicine + position requires combining an in-depth understanding of biological sciences with computational techniques in statistics and mathematics, and the ability to identify novel research opportunities and carrying them out independently and successfully + Develop, maintain, and utilize cutting-edge pipelines for the processing and analysis of high-throughput data to drive biological insights + Integrate ‘omics data and collaboratively leverage large-scale data mining of public and private resources to support biomarker and target discovery aims ***What the Computational Biologist need*** + Proficient in SQL, R and Python is a prerequisite, and demonstrated Linux/Unix scripting competency. + Demonstrated strong knowledge of NGS analysis & Statistics/ Data Modelling + Ph.D. and/or M.Sc. in a biology, genetics or a computer science field + Experience within open source development environments ***What the Computational Biologist will get*** + Excellent salary entirely dependant on experience + Very good benefits package + Experience working with some truly ground-breaking engineers & Scientists If this role sounds perfect for you, then get in touch today!

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  • Scientist, Phage Selections 3/19/2019 12:00:00 AM

    Salary: £0 Location: Cambridge

    The Client: My client is a biotech company based in Cambridge. Their new technology is used in development of a new and improved novel protein scaffold based on a human protease inhibitor. They’re considered to be the next generation of biotherapeutics, being superior to the current, monoclonal antibodies. Their products are used across a range of life sciences including therapeutics, R&D and diagnosis. They’re also in partnership with various pharmaceutical companies and due to the growing demand of their products, have decided to expand their laboratory operations and bring on scientists to assist with development. The role will involve designing and carrying out phage display selections, screening and characterisation of outputs to identify therapeutic candidates. Executing automated phage display panning against target proteins as well as characterisation using ELISA and some cell-based assays. You will also do some sequencing of phage candidates for small scale production and purification. Requirements: - BSc or MSc in molecular biology/biotechnology or similar field with 2 years lab experience - Experience of in vitro display technologies (phage, ribosome, yeast display, etc) - Knowledge in protein purification and characterisation using ELISA (HTRF and cell binding assays would be an advantage) - Organised with ability to work well under pressure - Strong analytical and critical thinking skills - Library design and construction experience will be a distinct advantage My client provides a supportive working environment using state-of-the-art equipment for talented individuals seeking a career at the cutting edge of biotechnology. Offering competitive salaries and a group personal pension scheme, they also provide extra days annual leave. Situated in a desired location, with opportunities to develop and advance your career. For more information about the role or for a chance to apply, please contact Philip Adebiyi on 0161 250 5049 or Philip.adebiyi@wearenorthpoint.com

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  • Lead Bio-Process Engineer 3/18/2019 12:00:00 AM

    Salary: £0 Location: Bristol

    Based in the Southwest of England, my client is looking to address some of the biggest global challenges facing ethical food sourcing and environmental impact. Using cutting edge cell culture techniques, they are looking to combine biotechnological advancements and create real meat without harming our health, planet and animals They are currently looking for a passionate and driven process engineer, with experience in cell/gene therapy technology development or engineering, to join their founding team! If you’re skilled, passionate, dedicated and looking for a role that can make an impact, this may be the role for you! Your responsibilities: As an engineer, passionate about process development and excited to scale up cell-based meat, you will oversee the modelling of processes and scale up to pilot plant. You will be responsible for designing and execute experiments in bioreactors including process and media optimisation, developing planning and co-ordinating projects and continuously improving on project execution. You will work closely with the rest of our founding team, advisors and partners to ensure that the R&D work is robust and scalable. You have: • +3 years within process development or cell/gene therapy technology development/engineering. • MSc, M.Eng or higher in Chemical Engineering / Bioengineering or another relevant subject • Experience in designing and operating bioreactors • Stem cell/mammalian cells bioprocessing experience • Comfortable developing PFD, P&IDs, mechanical designs, HAZOP and SOPs • Understanding of GMP and relevant ISOs • Experience with computer simulations Competitive salary: (based on experience) Excellent career opportunities

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  • Modelling and Simulation Research Fellow 3/15/2019 12:00:00 AM

    Salary: £0 Location: Nottingham

    Industry Based, Modelling and Simulation Research Fellow Based in Nottinghamshire, my client is a market leader in biotechnology and clinical manufacturing. Due to continued growth they are looking for a Modelling and Simulation Research Fellow, specialising in physiologically based pharmacokinetic (PBPK) modelling and simulation (M&S). The role will provide hands-on M&S scientific support and input through the life cycle of the project (design, planning, delivery and reporting). You will work closely with sponsors and internal teams to develop a thorough understanding of the biopharmaceutic, pharmacokinetic and metabolism profile of assigned compounds. Independently build and rigorously test PBPK models to support evaluation of absorption and systemic exposure potential for NCE’s. Use in vitro data and in silico tools to predict or describe the impact that formulation strategy/technology can have on in vivo performance. Provide in silico simulations to aid interim decision making during clinical studies regarding dose escalation and formulation selection. Investigate the existence of correlations between in vitro dissolution data and human plasma concentration-time data (IVIVCs) using either mechanistic models or traditional numerical deconvolution approaches. You will have: MSc or higher in a relevant life sciences subject with a significant component of Modelling and Simulation. 3-5 years relevant pharma, CRO/CDMO experience. Hands on experience in the use of M&S in a pre-clinical/translational setting (late stage discovery/early clinical R&D) is essential Experienced in one or more of the following; WinNonlin Phoenix, GastroPlus or SimCYP. Competitive salary EXcellent training and development State of the art facilities

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  • Protein Scientist 3/14/2019 12:00:00 AM

    Salary: £35000 Location: Cambridge

    My client is an industry leading life sciences company dedicated to providing Life Scientists with the high quality, unique and powerful tools they need to develop safe and novel diagnostics and treatments. Currently, the company are developing novel bio-therapeutics that will compete with monoclonal antibodies and antibody mimetics in the future of diagnostics and treatments. Due to recent expansion and growth, they are looking for two new scientists to join their Protein Scientists Team. Working in a state-of-the-art facility, you will be responsible for carrying out R&D projects to express and biophysically categorise novel proteins, identify therapeutic properties and produce high quality material for pre-clinical studies. What you will need • BSc or higher in Biochemistry/ Molecular biology or a related discipline • Be able to clone, express, purify and characterise proteins • Be able to work with protein expression platforms What you will get • Great career development opportunities • State-of-the-art laboratories • Great Benefits Package This a great opportunity to be part of a dynamic team developing unique and ground-breaking bio-therapeutics. Get in touch today to ensure that you don’t miss out!

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  • Group Leader – Fermentation 3/13/2019 12:00:00 AM

    Salary: £0 Location: Saffron walden

    My client is an industry leading biopharmaceutical company transforming personalised medicine with leading microbiome science. Their class-leading platform enables precise and large-scale identification, enabling the design of novel medicines and biomarkers based on live bacteria. In just two years, the company has established itself as an industry leader, having won four awards and recently signed a strategic multi-year deal with a US based biotech to discover novel biomarkers, targets and medicines in inflammatory bowel disease. They are now looking for a driven, organised and proactive individual to lead the Fermentation group in the Preclinical Development Team. The successful candidate will be responsible for in-house fermentation of multiple anaerobic gut bacteria that comprise the medicine, characterising and optimising their growth and providing support for upstream and downstream method development and optimisation. What you will do • Leading a small team, develop fermentation processes to produce live bacterial therapeutics comprising multiple bacterial strains • Performing anaerobic fermentation of bacteria from microtiter plates to small fermenters • Optimising media for growth of physiologically diverse bacteria • Supporting process transfer to CDMOs What you will need • PhD in a relevant discipline • 5 years post-doctoral experience in a bioprocess development environment utilising fermentation technology • Experience of optimising biotech processes and methodologies that can be applied to microbiome research • Ability to rigorously plan and accurately document research activities • Experience in leading small teams • Experience in handling and culturing anaerobic bacteria What you will get • State of the art facilities • Highly competitive salary • Competitive Benefits Package This is an exciting opportunity for an enthusiastic scientist to play a key role in building a young biotech company and to contribute to the development of a new class of medicines. Get in touch today to ensure that you don’t miss out!

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  • Cryo-EM Scientist - Software Programmer 3/6/2019 12:00:00 AM

    Salary: £0 Location: Cambridge

    My client is a world leading biotechnology company dedicated to the discovery and development of novel small molecule therapeutics. As part of my client’s on-going commitment to develop and expand their structural biology capabilities, their Molecular Sciences Group now has opportunities for highly-driven scientists to join the cryo-EM team. Working in a state-of-the-art facility, the cryo-EM scientist will be focussed on the development of the company’s cryo-EM data processing platform. What you will need • Ideally a PhD or MSc in a relevant scientific subject • experience of Python, HTML/JavaScript/CSS, SQL, Java or C++ • Strong theoretical understanding of cryo-EM • Have excellent communication skills and the ability to work in multi-disciplinary teams What you will do • Developing and enhancing capabilities for cryo-EM data processing • Monitoring and evaluating relevant image processing technologies • Database and user interface development • Collaborating on the development of cryo-EM software tools with software developers in the company What you will get • Excellent training and Career Development opportunities • State of the art facilities • Highly competitive salary • Great Benefits Package This a great opportunity for an innovative scientist wishing to develop their career in a thriving multidisciplinary, industrial environment. Get in touch today to ensure that you don’t miss out!

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  • (Senior) Research Scientist 3/6/2019 12:00:00 AM

    Salary: £0 Location: Saffron walden

    The Client: My client is a biotech company based in Saffron Walden. They are considered to be at the forefront of synthetic biology pursuing a mission to provide the fastest, most efficient engine for therapeutic antibody discovery. They are passionate about using their platform technologies to improve and accelerate drug discovery and development and are currently looking for 2 highly motivated and enthusiastic research scientists to join their dynamic team as well as 1 senior research scientist. The role will entail designing and carrying out selections and screening campaigns on antibody fragment libraries using phage display. You will be performing general molecular biology work (DNA purification, PCR setup) as well as some antibody sequence analysis. Techniques used include SDS-PAGE, western blot and chromatography in analysing protein expressions whilst also using ELISA in basic antibody assays. Requirements: - BSc, MSc or PhD (senior) in life sciences or any related field - 2 years experience in a relevant field, preferably biotech or pharmaceutical - Able to work effectively and prioritise deadlines - Able to work independently on own initiative as well as part of a team interacting with staff and partners alike - Knowledge of molecular and biology techniques like SDS-PAGE, ELISA and western blot - Knowledge and practical experience in phage display will be a huge advantage but not essential My client provides a supportive and creative working environment for talented individuals who are seeking a dynamic career at the cutting edge of biopharmaceutical research. Situated in a great location, close to Cambridge with state-of-the-art facilities and equipment. They offer competitive salaries and an attractive benefits package. For more information about the role or for a chance to apply, please contact Philip Adebiyi on 0161 250 5049 or Philip.Adebiyi@wearenorthpoint.com

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  • Cryo-EM Scientist - Facilities 3/6/2019 12:00:00 AM

    Salary: £0 Location: Cambridge

    My client is a world leading biotechnology company dedicated to the discovery and development of novel small molecule therapeutics. As part of my client’s on-going commitment to develop and expand their structural biology capabilities, their Molecular Sciences Group now has opportunities for highly-driven scientists to join the cryo-EM team. Working in a state-of-the-art facility, the cryo-EM scientist will be primarily focused on the expansion and maintenance of the cryo-EM facility. What you will need • Ideally a PhD or MSc in a relevant scientific subject • Experience maintaining cryo-EM microscopes • Strong theoretical understanding of cryo-EM • Have excellent communication skills and the ability to work in multi-disciplinary teams What you will do • Management, operation and maintenance of cryo-EM microscopes and the associated infrastructure • Training and assisting users in cryo-EM sample preparation, optimisation and data collection • Developing sample preparation and characterisation work flows • Optimising data collection strategies and processes • Engaging with structure-based drug discovery programs What you will get • Excellent training and Career Development opportunities • State of the art facilities • Highly competitive salary • Great Benefits Package This a great opportunity for an innovative scientist wishing to develop their career in a thriving multidisciplinary, industrial environment. Get in touch today to ensure that you don’t miss out!

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