Biotechnology

  • Group Leader – Fermentation 1/15/2019 12:00:00 AM

    Salary: £0 Location: Saffron walden

    Our client’s class-leading platform enables precise and large-scale identification, enabling the design of novel medicines and biomarkers based on live bacteria. In just two years, the company has established itself as an industry leader, having won four awards and recently signed a strategic multi-year deal with a US based biotech to discover novel biomarkers, targets and medicines in inflammatory bowel disease. Our client is now seeking a driven, organised and proactive individual to lead the Fermentation group in the Preclinical Development Team. This is an exciting opportunity for an enthusiastic scientist to play a key role in building a young biotech company and to contribute to the development of a new class of medicines. The major areas of responsibility are: + Leading a small team, develop fermentation processes to produce live bacterial therapeutics comprising multiple bacterial strains. + Performing anaerobic fermentation of bacteria from microtiter plates to small fermenters. + Maintaining an awareness of latest technologies and equipment for incorporation into company labs. + Supporting process transfer to CDMOs. Candidate Specifications: Essential requirements for this post include: PhD in relevant discipline eg: Microbiology or Bioprocess Engineering with focus on fermentation and cell harvest or experience in equivalent closely-related discipline. 5 years post-doctoral experience in a bioprocess development environment utilising fermentation technology. Experience of optimising biotech processes and methodologies that can be applied to microbiome research. Ability to rigorously plan and accurately document research activities For more information regarding this incredible opportunity, please contact Robert Frame on 0161 923 8189 robert.frame@wearenorthpoint.com

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  • Senior Process Development Engineer 1/14/2019 12:00:00 AM

    Salary: £0 Location: Hertfordshire

    My client is an award-winning clean technology company that makes and is researching biofuels. They are looking for a new Senior Process Development Engineer to join their Commercial and Product Development Team. Main Duties and Responsibilities • Direct the design, research and development of new products from initial concepts through to prototyping, pre-production and final release • Conduct product and process development on biochemicals and solid fuels from spent coffee grounds • Design, conduct experiments and lead in-house trials and at tolling partner sites • Identify suitable third-party partners (including toll manufacturers) • Collect pertinent data/information, developing detailed engineering calculations, and writing formal engineering/technical reports • Contribute to invention disclosures, patents and publications • Review and sign-off product and process specifications • Manage, mentor and engage in the development of junior engineers in the team • Work with commercial lead on customer requirements • Liaise with engineering/operations team regarding processes for front end handling etc • Manage relationships with toll manufacturers, trial partners and others • Participate in technical meetings and handle discussions with third parties and colleagues What you will need • Master’s Degree in Chemical Engineering or a related engineering discipline • A minimum of 3 years industrial experience in process and product development • Experience in process design, scaling up to full plant design and commissioning • Ability to independently design, plan and execute projects and project tasks and scientific research and development is required • Expert-level with processing and formulation equipment, plant layouts, and concepts/procedures for equipment design and sizing • Demonstration of customer focus and ability to respond to customer needs whilst achieving project and business objectives What you will get • Great Career Development Opportunities • Competitive Salary • Great Benefits Package This a great opportunity to be part of a dynamic team conducting ground-breaking research in biofuels. Get in touch today to ensure that you don’t miss out!

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  • Process Engineer 1/10/2019 12:00:00 AM

    Salary: £0 Location: Bristol

    We’re looking for engineers passionate about process development and excited to scale up cell-based meat! As a process engineer you will oversee the modelling of my clients process and scale up to pilot plant. You will be responsible for designing and executing experiments in bioreactors including process and media optimisation. You will develop, plan and coordinate engineering projects, continuously improving on project execution. You will work closely with the rest of the founding team, advisors and partners to ensure that the R&D work is robust and scalable. This job might be for you if you: + 3 years within process development or cell/gene therapy technology development/engineering. + Understanding of GMP and relevant ISOs. + Experience with computer simulations. + Experience in designing and operating bioreactors. + Comfortable developing PFD, P&IDs, mechanical designs, HAZOP and SOPs. + Stem cell/mammalian cells bioprocessing experience. + Experience with technology transfer and scale-up is a plus. + Have the ability to have fun and inspire team members to enjoy work, be action-oriented and stretch their imagination. For more information regarding this fantastic opportunity please contact Robert Frame on 0161 923 8189 or robert.frame@wearenorthpoint.co.uk

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  • Compliance Engineer 1/9/2019 12:00:00 AM

    Salary: £0 Location: Salisbury

    My client is a fast-growing biopharmaceutical manufacturing company keen to recruit talented individuals to be part of a team producing safe and high-quality lifesaving products. Due to recent expansion and growth, they are looking for new Compliance Engineers to join their Engineering Team. Main Duties and Responsibilities • To lead the investigation and root cause analysis determination of deviations within integrated process teams (IPTs) through the PBL non-conformance system • To initiate and support Process Engineers and Process Equipment Engineers in the completion of continuous improvement actions and CAPA actions • To support the Quality Engineer ensure the timely compliance of activities managed by the PBL QMS within agreed timelines • To support the Process Engineers and Process Equipment Engineers in fault finding following failures or performance issues and to support the coordination of planned and corrective engineering activities such as maintenance and calibration • To monitor the performance of critical systems supporting manufacturing including HVAC and critical utilities • To be responsible for the maintenance and update of Standard Operating Procedures relating to Engineering work flows. • To maintain visual status information relating the Engineering function within the ITPs What you will need • Holds A/AS Level qualifications (or an equivalent academic or vocational qualification) • Previous practical experience of leading Root Cause investigations, either solely or as part of an investigation team and implementing Corrective and Preventative actions • Experience of working within a GMP Quality System, in particular, change control, Non Conformance management, CAPA, discrepancy/deviation, and documentation management. • Experience of dealing with internal customers, negotiating and agreeing work programmes, reporting progress, dealing with issues to ensure delivery and customer satisfaction What you will get • Competitive Salary • Great Benefits Package This a great opportunity to be part of a dynamic team manufacturing life-saving therapeutics. Get in touch today to ensure that you don’t miss out!

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  • Interim Microbiologist 1/7/2019 12:00:00 AM

    Salary: £0 Location: Shepherds bush

    My client specializes in the application of imaging in drug research and have experience working in multiple therapeutic areas. Since their founding, my client has worked hard to expand their domain knowledge across both research and therapeutic disciplines. The team takes pride not only in the quality of their services and software offerings, but also in the innovations they have brought to the research community. This is an exciting opportunity for a microbiologist to join my client at this very exciting time. Additionally, my client is an expanding company, providing imaging services in support of translational drug discovery and drug development. To be considered for this position you will have: + A BSc/MSc Degree or equivalent in a relevant field. + Experience of working in microbiology, specifically supporting sterility testing and environmental monitoring activities. + Preferably, experience of working with short-lived radioisotopes (Especially Carbon-11 and Fluorine 18). + Good understanding of GMP and ability to front external audits. The role will be responsible for: + Ensuring day-to-day running of Microbiology laboratory. + Performing in-house sterility testing on radiotracers and managing contractor companies for outsourced microbiological testing. + Documenting microbiological records to ensure compliance with cGMP. + Responsible for microbiological test implementation of new radiotracers: method development, validation and documentation. + Taking the leadership for assembly of sterile vials used in PET (Positron Emission Tomography) product manufacture. + Performing routine QC testing to support clinical and pre-clinical studies when required. + Validation and Qualification of Isolators Gassing Cycles. + Monitoring of water systems used in PET product manufacture. For more information on this role please contact Robert Frame on 0161 923 8189 or robert.frame@wearenorthpoint.co.uk

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  • Research Associate, Quality Control 1/7/2019 12:00:00 AM

    Salary: £0 Location: Oxford

    My client is a leading therapeutic manufacture focusing their work on developing leading T-cell inducing vaccine products to improve global health. Based in Oxford my client is an up and coming regulatory and manufacturing company, specialising in next generation biotechnology. They have an exciting opportunity for a research scientist to join their team with experience in analytics. The work will primarily be focused on viral vectored vaccines research and development. You must be a self-starter with the ability to work in a fast-paced environment and adapt quickly to changing needs and priorities; proven ability to prioritize and manage multiple tasks simultaneously. The successful candidate will play an integral role in conducting bench studies to support vector production and process development to progress the adenovirus and the MVA vaccine vector platforms. ESSENTIAL DUTIES AND RESPONSIBILITIES: + Perform routine quality control assays on viral vectored vaccine preparations (physical titer, infectious titer, sequence verification, transgene expression). + Support the Senior Scientist in tech transfer of routine analytical techniques used for the testing of viral vectored vaccines. + Assist in the development of new analytical assays, including the use of flow cytometry, qPCR, next-generation sequencing, SDS-PAGE, ELISA. + Evaluate and perform analytic assays to determine the quality, yield, stability, etc. of specific candidates or of specific manufacturing process conditions. + Work under GLP-like conditions, with the appropriate requisite training, documentation, and attention to following defined Operating Procedures or Work Flow diagrams. + Bsc with At least 2 years of relevant work experience, ideally in industry, with demonstrated experience in analytical laboratory work with biologicals. + Proficient in conducting research using a variety of assays/methodologies; e.g. viral titers, PCR/qPCR, DNA sequence interpretation, ELISA, western blot. For more information on the role please contact Robert Frame on 0161 923 8189 or robert.frame@wearenorthpoint.co.uk

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  • Senior Scientist, Analytics 1/7/2019 12:00:00 AM

    Salary: £0 Location: Oxford

    My client is a leading therapeutic manufacture focusing their work on developing leading T-cell inducing vaccine products to improve global health. Based in Oxford my client is an up and coming regulatory and manufacturing company, specialising in next generation biotechnology. They have an exciting opportunity for a senior scientist to join their team with experience in analytics. The work will primarily be focused on viral vectored vaccines research and development. You must be a self-starter with the ability to work in a fast-paced environment and adapt quickly to changing needs and priorities; proven ability to prioritize and manage multiple tasks simultaneously. The successful candidate will perform existing quality control assays as well as play a critical role in the development of new analytical methods to characterise viral vaccine vectors, including (but not limited to) adenoviral and poxviral vectors. ESSENTIAL DUTIES AND RESPONSIBILITIES: + Perform routine quality control assays on viral vectored vaccine preparations (physical titer, infectious titer, sequence verification, transgene expression) + Lead, support and perform Tech transfer of routine analytical techniques used for the testing of viral vectored vaccines. + Lead the development of new analytical assays, including the use of flow cytometry, qPCR, next-generation sequencing, SDS-PAGE, ELISA + Ensure data integrity is maintained for all work performed. + Lead, participate in the investigation or review of quality deviations and out of specification results. + PhD with more than 2 – 5 years of relevant experience in industry (Molecular Biology, Biochemistry, or Analytical Methods development). + Applicants must have a solid background in one of the following areas: Quality control methods for biologics, including qPCR or Viral vector characterisation assays. + Extensive interpersonal and management skills, with ability to work independently and collaboratively with other scientists and laboratorians. For more information on the role please contact Robert Frame on 0161 923 8189 or robert.frame@wearenorthpoint.co.uk

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  • Instrument Engineer 1/3/2019 12:00:00 AM

    Salary: £0 Location: Nottingham

    My client helps biopharmaceutical companies improve patient outcomes with a range of technologies that facilitate the development of superior biotherapeutics. The company is now looking to add to their team and bring in an Instrument Engineer, you’ll be joining a team of 7. This person will be responsible for engineering maintenance activities to ensure our manufacturing facility runs on schedule and to defined standards. You will also support small engineering projects and larger capital investments, within a highly regulated and controlled cGMP environment. ***What the Instrument Engineer will do*** + Ensuring maintenance activities are carried out in a safe, compliant and timely manner within the established KPI framework + Provision of routine out-of-hour’s emergency call-out support on the engineering call-out Rota + To contribute and provide support as required for large capital investment projects + To provide support to Electrical and Mechanical engineering when appropriate ***What the Instrument Engineer will need*** + Familiarity with standard industrial electrical LV infrastructure. Experience of control systems (conventional/PLC), VSDs, motor control, process instrumentation, BMS and SCADA systems would be a distinct advantage + C&G 2382 17th/18th Edition certification and C&G 2394/2395 (or equivalent) in Inspection and Testing + Industry recognised Instrument Engineering qualification + Ability to work on the out of hours on call rota (£5000 per annum) ***What the Instrument Engineer will get*** + Salary up to £35,000 basic salary + Bonus paid annually up to 5% + Pension & optional private health cover + Free parking

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  • Protein Scientist 1/2/2019 12:00:00 AM

    Salary: £0 Location: Cambridge

    My client is an industry leading life sciences company dedicated to providing Life Scientists with the high quality, unique and powerful tools they need to develop safe and novel diagnostics and treatments. Currently, the company are developing novel bio-therapeutics that will compete with monoclonal antibodies and antibody mimetics in the future of diagnostics and treatments. Due to recent expansion and growth, they are looking for two new scientists to join their Protein Scientists Team. Working in a state-of-the-art facility, you will be responsible for carrying out R&D projects to express and biophysically categorise novel proteins, identify therapeutic properties and produce high quality material for pre-clinical studies. What you will need • BSc or higher in Biochemistry/ Molecular biology or a related discipline • Be able to clone, express, purify and characterise proteins • Be able to work with protein expression platforms What you will get • Great career development opportunities • State-of-the-art laboratories • Great Benefits Package This a great opportunity to be part of a dynamic team developing unique and ground-breaking bio-therapeutics. Get in touch today to ensure that you don’t miss out!

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  • Electrical Engineer 12/19/2018 12:00:00 AM

    Salary: £35000 Location: Nottingham

    My client helps biopharmaceutical companies improve patient outcomes with a range of technologies that facilitate the development of superior biotherapeutics. The company is now looking to add to their team and bring in an Electrical Engineer, you’ll be joining a team of 7. This person will be responsible for engineering maintenance activities to ensure our manufacturing facility runs on schedule and to defined standards. You will also support small engineering projects and larger capital investments, within a highly regulated and controlled cGMP environment. ***What the Electrical Engineer will do*** + Project management of small engineering projects + Assisting with writing and reviewing routine documentation such as SOPs, risk assessments, method statements and change requests + To contribute and provide support as required for large capital investment projects + Perform maintenance activities in a safe, compliant and timely manner within the established KPI framework ***What the Electrical Engineer will need*** + Familiarity with standard industrial electrical LV infrastructure. Experience of control systems (conventional/PLC), VSDs, motor control, process instrumentation, BMS and SCADA systems would be a distinct advantage + C&G 2382 17th/18th Edition certification and C&G 2394/2395 (or equivalent) in Inspection and Testing + Industry recognised electrical engineering qualification + Ability to work on the out of hours on call rota (£5000 per annum) ***What the Electrical Engineer will get*** + Salary up to £35,000 basic salary + Bonus paid annually up to 5% + Pension & optional private health cover + Free parking

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