Biotechnology

  • Protein Biochemistry Team Leader 4/23/2018 12:00:00 AM

    Salary: £50000 Location: OXFORD

    The Client My client offers unique solutions for preclinical and clinical immunology research, including a comprehensive and integrated antigen characterization platform, and products and services for tracking antigen-specific immune responses with state-of-the-art ELISpot and flow cytometry techniques. The Role They are now seeking a highly-motivated Protein Biochemistry Team Leader with primary responsibility for ensuring that the core product processes run smoothly, and deliver high quality products to their customers. The successful candidate will report directly to senior management and have direct line management responsibility for 3-5 team members. The scope of the role is varied and encompasses technical, operations and team management aspects. Responsibilities • Ensure that work orders are processed and delivered on time • Supervise the lab work and duties of team members, as well as provide training and support where needed • Contribute to research work relating to development of new products as well as application support for existing products • Continuously improve our production processes in line with technological best practice and contribute to developing in-house expertise in specialist techniques • Build and maintain strategic supplier relationships; source input materials and equipment for our products • Maintain links with other internal departments to form collaborations, share resources and data • Manage operational aspects including equipment maintenance, budgeting and stock tracking • Maintain and improve quality control systems in compliance with our ISO 9001:2015 quality management system. Salary is negotiable on experience Are you prepared to begin a new chapter in your career? If so, this could be the role for you! For more information and a confidential discussion, please contact Kieran Whittaker on: - Tel: - 0161 923 8174 Email: - Kieran.whittaker@wearenorthpoint.com

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  • Study Director - Chromatography 4/19/2018 12:00:00 AM

    Salary: £40000 Location: BRADFORD

    My client are a multinational business with laboratories thorughout the UK focusing on pharmaceutical, biotechnology, food, environmnetal, agrochemical, petrochemical and chemical sectors. Due to expansion, there is an urgent need for a Study Director with experience in analytical sciences. * GC/MS * LC/MS *Experience of working to GLP and following SOPs *Previous experience as a Study Director or Technical expert preferred If you are looking for a new position and would like to know more, please do get in touch.

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  • Regulatory Affairs Manager 4/19/2018 12:00:00 AM

    Salary: £55000 Location: STEVENAGE

    My Client are a leading Cell and Gene Therapy company looking to attract a Regulatory Affairs Manager for a 9 month FTC. With offices across the UK and a translational therapeutics pipeline secured over the next 5 years, this is a great position for someone looking to gain managerial experience within a world class environment. Responsibilities: To support the development programmes in place, providing expert advice to ensure the programmes are developed in a way which meet regulatory requirements; To provide expertise in CMC requirements of product and process development To implement optimal regulatory strategies for each programme in agreement with the Head of Regulatory Affairs, Knowledge of advanced therapy clinical trial applications and GMM submissions to support gene therapy clinical trial applications. Please contact Adam Robinson for more information!

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  • Clinical Immunologist - PRO-DEV-CLIN 4/19/2018 12:00:00 AM

    Salary: £38000 Location: MOTHERWELL

    The Client My clients mission is to develop and commercialise innovative cell-based products to treat disease, improving patient health and Quality of Life. A clinical development company based in Scotland, with a cell-based product pipeline capable of treating a variety of disorders including cancer and severe viral infections. My client is currently conducting Phase II/III clinical studies of its lead product, in renal cell cancinoma, non-small cell lung cancer and melanoma patients. The Role If you are passionate about cancer immunotherapy and are looking to work within a challenging, dynamic, and rewarding environment, then this company represents an excellent career move. This is an opportunity to be part of a growing, ambitious business where people development is critical to future success. As they continue to expand, there will be career opportunities on a global scale. My client is an emerging cancer immunotherapy company developing cell-based treatments for cancer and severe viral infections. Based in the central belt of Scotland, the successful candidates will form an integral part of my clients rapidly expanding Product Development team, which is responsible for delivering the preclinical portfolio of ?d T cell-based therapies. Responsibilities The Senior Scientists and Scientists in Clinical Immunology will work within the Product Development team and, providing specialist knowledge and experience of working with patient-derived samples, will apply their expertise to the design, implementation and completion of projects crucial to the CAR-T and allogeneic pipelines. In particular, the post-holder will contribute/lead in developing and transferring methods for successful expansion, transduction and assays of patient-derived material, especially in the ImmuniCAR project. However, the successful candidate will also be expected to become actively involved across the range of pipeline products to aid the Product Development team in achieving their aims. To successfully achieve the project objectives, the post-holder will be expected to apply expertise across a number of practical skills, including primary cell culture (isolation, expansion and assay development), flow cytometry and cryopreservation of cell banks. Other responsibilities will include support of other departments, the training and supervision of junior team members and contribution to general lab maintenance compliant with GMP procedures. • Perform cell isolation from both healthy donors and patient-derived materials • Optimize methods for the isolation, expansion, transduction and differentiation of specific subsets of PBMCs from patients with a range of indications • Undertake cell culture of primary immune cells, cancer cells and immortalised cell lines and perform functional cell-based assays such as cytotoxicity and proliferation assays. • Design and perform multiparameter flow cytometry experiments • Develop SOPs for the use of patient or donor-derived material for clinical applications • Devise assays to Quality Control the final cell therapy product and liaise to transfer release assays to other departments • Work both independently and with the team to analyse data generated from experiments, draw appropriate conclusions and decide upon next steps. • Maintain documentation to appropriate quality standards, including, but not limited to, laboratory notebooks, standard operating procedures, COSHH/BIOCOSHH assessments and Risk Assessments. • Carry out literature reviews and collate information to identify information useful for the development of novel assays or the improvement of current processes and, where appropriate, to prepare applications to protect intellectual property The Candidate • Have significant experience working in research or biomedical laboratories, ideally holding an advanced degree (PhD or Masters) in a relevant subject • Have extensive knowledge of cell therapy and, ideally, proven experience gained in an industrial setting. • Be experienced in working with patient and healthy human donor material across a range of applications, including cell culture, cell-based assays, and flow cytometry, as appropriate to the role. • Be familiar with GxP procedures, ideally in a cell therapy context. • Have experience in controlled document preparation • Have a keen interest in cell-based therapies and their application to treat cancer and viral/bacterial infections. • Have excellent team working and communication skills Salary is negotiable on experience

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