Biotechnology

  • Qualified Person 8/20/2018 12:00:00 AM

    Salary: £0 Location: Stevenage

    The Client My client, based in Stevenage, are specialists in helping Cell and Gene therapy companies translate early stage research into quality, commercially viable, scalable and investable therapies. With a team of over 120 Cell and Gene therapy experts and state-of-the-art development and viral vector labs, my client has ensured they remain a Centre of Excellence in this field. The Role The Qualified Person (QP) will participate in the translation of strategic direction into a Quality framework that defines, directs and governs the tactical application of GMP compliance for the Manufacturing Centre. In the first instance, this will be predominantly focused on developing and supporting the delivery of a fit for purpose Quality Management System and providing practical quality subject matter expertise to both CGT and collaborating residents (“Collaborators”). This activity will be required to support the initial grant of the facility MIA and MIA(IMP), and then to support on-going operations. The Manufacturing Centre hosts Collaborator manufacturing activities. You will perform batch certification for Collaborator manufacturing activities, as required, and act as a QP for the Manufacturing Centre. Responsibilities • Direct report to the Head of QA with close interaction with the Manufacturing Centre Management Team • Provide subject matter expertise in quality assurance, aseptic manufacturing and environmental microbiology to Manufacturing Centre staff and Collaborators • Ideally, act as Site Microbiologist, otherwise provide expert advice on Annex 1 requirements by approving the facility environmental monitoring, gowning and cleaning regimes. • Provide expert advice for microbiology changes and deviations and coach QC staff on microbiology as required (note: line management of the microbiology laboratories is not a part of this job specification) • Ensure the QMS is fit for purpose for a multi-purpose, multi-client facility, and maintain processes to ensure site compliance to the QMS • Maintain processes for batch certification for Collaborators and perform batch certification of ATMPs and or ATIMPs for Collaborators • Perform QP approval of Manufacturing Centre data (e.g. environmental monitoring data) to support certification by Collaborator QPs, Product Quality Reviews etc. • Develop and maintain QP to QP Agreements, as required, with Collaborator QPs • Represent the Manufacturing Centre as a QP, to external regulators, inspectors and Collaborators • Participate in the preparation and management of regulatory agency and client inspections, including co-hosting as required. Salary is negotiable on experience ---- For more information and a confidential discussion, please contact Kieran Whittaker on the below: - Tel: 0161 923 8174 Email: Kieran.Whittaker@wearenorthpoint.co.uk

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  • Bioinformatics – NGS Data Analysis 8/10/2018 12:00:00 AM

    Salary: £38000 Location: Oxford

    The company I am hiring for is a leader in synthetic biology, is a specialised contract research organisation offering services to support the discovery, development and production of biologics, with a focus on viral vectors for gene therapy applications. I am looking for an experienced and self-motivated bioinformatician to design, implement and run software pipelines for analysing next-generation sequencing (NGS) data. The successful applicant will be located within purpose-fitted laboratories at the Oxford Science Park. ***What the Bioinformatician will do*** + Build state-of-the-art data processing pipelines for targeted re-sequencing, whole genome sequencing, genome editing, and differential expression analysis experiments + Support our wet lab scientists in the planning, and interpretation, evaluation and visualisation of results for investigations with an NGS component + Stay up-to-date with new developments, technologies and methods in NGS data analysis, and proactively seek out collaborations with our group leaders to develop and extend our intellectual property portfolio in this area ***What the Bioinformatician will need*** + MSc/BSc in bioinformatics, computational biology, computer science or a related field, or equivalent experience in a biotechnology research environment + Programming experience with one or more of Python, Perl, Java and R, and familiarity with associated numerical analysis libraries (e.g. NumPy for Python, ND4J for Java, ect.) + Analysis experience with NGS datasets (preferably Illumina paired-end, PacBio or Nanopore) in DNA-seq, RNA-seq, break-seq, GUIDE-seq or similar contexts ***What the Bioinformatician will need get*** + Competitive Salary up to £38,000 + Work in state-of-the-art facility and sector + Excellent benefits & training opportunities If this sounds like the perfect role for you, then please get I touch today!

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  • Research Assistant (Discovery I (Host) Team) 8/7/2018 12:00:00 AM

    Salary: £28000 Location: Aberdeen

    Based in Aberdeen, my client a pharmaceutical company focussed on developing several biotherapeutics based on the human gut microbiome. They are currently looking for candidates for their research assistant position and are seeking candidates with the following skills; + Degree or Higher National Certificate in molecular biology, biomedical sciences, or other science-related discipline (preferably at MSc level) or at least 3 years’ experience working in an industrial environment in a similar role + Competency in cell culture techniques, including isolation and culture of primary cells from tissue samples (e.g. gut, spleen) and human specimens + Competency in immunological techniques (e.g. flow cytometry, ELISA, Bead Arrays) + Ability to keep accurate and detailed records of produced results + Good organisational and communication skills + Experience with basic microbiology techniques would be desirable Salaries for the position are expected to be up to around 28k.

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  • Research Assistant- (Discovery II Host Team) 8/7/2018 12:00:00 AM

    Salary: £28000 Location: Aberdeen

    Based in Aberdeen, my client a pharmaceutical company focussed on developing several biotherapeutics based on the human gut microbiome. They are currently looking for candidates for their research assistant position and are seeking candidates with the following skills; + BSc Degree or Higher National Certificate in molecular biology, microbiology, biomedical sciences, or other science-related discipline + Experience with cell culture techniques + Experience in a variety of basic immunological laboratory techniques, including nucleic acid extraction and qPCR + Ability to keep accurate and detailed records of produced results + Good organisational and communication skills The role offers excellent chance to progress with an internationally renowned organisation. Salaries for the position are expected to be in the 25-28k area with additional benefits.

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  • Post Doc Upstream Scientist 7/26/2018 12:00:00 AM

    Salary: £35000 Location: Cambridge

    My client is a leading biotechnology company developing novel drugs for the treatment of bacterial infections, to address the serious issue of increased antibiotic resistance worldwide. Due to current expansion they are currently hiring for a research upstream scientist to join the team, with a working knowledge and practical experience with cell cultures and cell banking. Position: Senior Upstream Fermentation Scientist – Biotechnology company based in Cambridge. Perfect first position in industry for a PHD with a strong focus on Microbial Fermentation, bioprocessing, Upstream etc. Expanding biotech conducting cutting edge research in antibiotic resistance Key focus on development in role. The line manager is keen to bring on a PHD candidate and focus on training and development. 1. Design, develop and optimise bacterial fermentation processes suitable for manufacturing. 2. Work with production methods such as shake flasks, 1L Glass bioreactors up to 15L scale stainless steel fermentation systems. 3. Ensure laboratory notebooks and/or Batch Manufacturing Records are completed and maintained according to Standard Operating Procedures (SOP). 4. To form part of multidisciplinary teams working within all areas of the Process Development team, and provide results, data and progress to project leaders. Role requirements: To be successful in your application to this exciting opportunity as the Fermentation Scientist we are looking to identify the following on your profile and past history: 1. Proven industry experience in developing and/or optimising methods for biopharmaceutical manufacturing. 2. Relevant PhD and extensive laboratory experience in a Life Science discipline such as Biochemistry, Biotechnology, Biochemical Engineering etc. as well as experience of working to a GMP biopharmaceutical environment.

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  • Scientist, Phage Selections 7/24/2018 12:00:00 AM

    Salary: £50000 Location: Cambridge

    Based in Cambridge my client is a market leader in bio-therapeutics. Due to continued growth the company are looking to develop a new pipeline of products targeted to oncology and inflammatory diseases and are looking for Senior Scientist in Phage Selections to join their team. You will be responsible for designing and carrying out phage display selections, screening and characterisation of outputs in order to identify lead Affimer therapeutic candidates. You will have: Essential skills and previous experience •MSc or higher in protein biochemistry/molecular biology with a minimum of 2-4 years’ laboratory experience or equivalent. •A minimum of 2 years’ laboratory experience of working in the field of in vitro display technologies (one or more of phage display, ribosome display, yeast display etc.) •A high level of lab-based competency in molecular biology, manipulating DNA and creating expression constructs. •Experience of characterising protein-protein interactions using at least two of the following methods; ELISA, HTRF, cell-based assays, SPR or BLI Salary from £30,000- £50,000 depending on experience Fantastic career opportunities State of the art facilities

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  • Product Steward 7/24/2018 12:00:00 AM

    Salary: £0 Location: Oxford

    Product Steward- Oxfordshire- Biotechnology- UP to £50k Based in Oxfordshire, my client is a world leader in Gene and Cell Therapy technologies. Due to a fantastic period of growth they have an exciting opportunity for a motivated and experienced Product Steward to join their team. You will be responsible for product stewardship, managing the continued process verification for the clinical/ commercial products and technical oversight of each products’ process performance and capability as well as maintaining oversight of post-approval CMC changes to ensure consistency and a timely implementation. You will also Act as a single point of contact for internal stakeholder and strategic partner queries regarding the products as well as leading the root cause investigations into process excursions (OOS/OOE/OOT) including CAPA implementation. You will have: BSc or higher in a life science, biotechnology, chemical engineering or another related discipline A strong track record and knowledge of bioprocess development, scale-up and GMP manufacturing (including large scale mammalian cell culture support) Significant experience in GMP manufacturing/ manufacturing science and technology/technical development/Quality Excellent analytical, organisational and problem-solving skills Fundamental understanding of standard pharmaceutical analytical testing Expert in reviewing and writing technical reports. Great salary: up to £52,000 (dependant on experience) Fantastic career development opportunities

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  • Laboratory Manager 7/19/2018 12:00:00 AM

    Salary: £38000 Location: Warrington

    My client is an award-winning microbiology contract tester. The company specialise in tailoring anti-microbial assays as well as supporting clients through regulatory approval processes. The client has undergone recent expansion and is currently hiring an experienced microbiology laboratory manager. They will be responsible for the management and motivation of the current, dynamic, laboratory team as well as playing a pivotal role in the client’s future strategy by managing, planning and delivering projects to both current and prospective clients. My Client is looking for an experienced laboratory manager who has worked in a fast-paced microbiology environment. Experience in managing, planning and delivering multiple projects is essential to the role. The candidate must be well organised and be an effective communicator, with experience in managing and supporting a laboratory team previously. Salary: £30,000 - £38,000

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  • Senior Protein Scientist 7/16/2018 12:00:00 AM

    Salary: £50000 Location: Cambridge

    Based in Cambridge my client is a market leader in bio-therapeutics. Due to continued growth the company are looking to develop a new pipeline of products targeted to oncology and inflammatory diseases and are looking for Protein Scientist and Senior Protein Scientist to join their team. You will be responsible for Cloning, expressing, purifying and characterising Affimer proteins for protein characterisation work, binding studies and stability testing using a range of different expression platforms (bacterial, Pichia or mammalian cells). You will also need to be comfortable Presenting work/data at internal group or company meetings when required. You will have: A BSc or higher in protein biochemistry, protein engineering, molecular biology or another relevant subject. (Senior scientist would need lab experience working with therapeutic protein scaffolds or antibodies) Standard DNA manipulation/cloning techniques and protein engineering including working with a range of protein expression platforms (bacterial, Pichia and mammalian) Mammalian cell culture - culturing and maintaining cell lines, transfections for protein production. Large scale protein production experience would be an advantage Practical knowledge of the AKTA purification platform and conventional chromatography resins e.g. ion exchange Developing HPLC based assays for protein characterisation Excellent knowledge of a range of methodologies to characterise proteins (e.g. SPR, ELISA, Western blot). Salary from £30- £50,000 depending on experience Fantastic career opportunities State of the art facilities

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  • Scientist, Assay Development 7/16/2018 12:00:00 AM

    Salary: £35000 Location: Cambridge

    Assay Development Scientist Based in Cambridge my client is a market leader in bio-therapeutics. Due to continued growth the company are looking to develop a new pipeline of products targeted to oncology and inflammatory diseases and are looking for a Assay Development Scientist to join their team. You will be responsible for developing a range of cell based/binding assays to support Affimer screening, characterise our lead molecules for biological functionality and to support our pre-clinical assay development/cell biology needs. This role will suit someone who has experience in screening and characterising protein fragment technologies or antibodies for therapeutic applications. A BSc or higher in cell or molecular biology or another relevant subject focusing on immunology or oncology •Hands on experience of working with and developing assays for therapeutic protein scaffolds or antibodies •Be able to demonstrate a strong ability to develop target binding (e.g. RBA, ELISA, Alpha-screen and HTRF) and phenotypic based assays (phosphorylation, cell proliferation etc.) using a range of techniques (e.g. Western blot, flow cytometry, confocal microscopy and IHC) •Experience of isolating, working with and maintaining primary cell lines in culture •Being able to carry out mammalian transfections with plasmid DNA and maintain transient or stable mammalian cell lines Salary up to £35,000 depending on experience Fantastic career opportunities State of the art facilities

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