Biotechnology

  • Scientist, Phage Selections 4/10/2019 12:00:00 AM

    Salary: £0 Location: Cambridge

    My client is an industry leading life sciences company dedicated to providing Life Scientists with the high quality, unique and powerful tools they need to develop safe and novel diagnostics and treatments. Currently, the company are developing novel bio-therapeutics that will compete with monoclonal antibodies and antibody mimetics in the future of diagnostics and treatments. Due to recent expansion and growth, they are looking for enthusiastic (Senior) Scientists to join their Discovery Team. Working in a state-of-the-art facility, your role will be to design and carry out phage display selections, screening and characterisation of outputs in order to identify lead therapeutic candidates. What you will need • A BSc or MSc in a biological discipline • A minimum of 2 years’ laboratory experience • A high level of lab-based competency in molecular biology, manipulating DNA and creating expression constructs. • Excellent aseptic technique and microbiology techniques • A good understanding of characterising protein-protein interactions using a variety of assays (e.g. ELISA, cell-based assays, Biacore/Octet etc.) • Experience of recombinant E.coli expression systems, protein purification and characterisation (SDS-PAGE, Western blot etc.) What you will get • State-of-the-art laboratories • Competitive Salary • Great Benefits Package This a great opportunity to be part of a dynamic team developing unique and ground-breaking bio-therapeutics. Get in touch today to ensure that you don’t miss out!

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  • Senior Mechanical Engineer 4/3/2019 12:00:00 AM

    Salary: £0 Location: Oxford

    Senior Mechanical Design Engineer - Oxford, UK Based in Oxford my client is a specialist in DNA analysis. Due to continues growth they are looking for a highly motivated and hands on, Senior Engineer, to join the team. The team includes over 30 engineers, with core strengths in mechanical, fluidic, electronic, firmware, and production engineering. This role will have a focus on Mechanical/ Development engineering and will sit within their new products/R&D team. And you will need to show a high level of enthusiasm for problem solving and attention to detail. You will be responsible for: Creating innovative concepts to address the technical needs of new products- Conducting design feasibility studies; detailing assumptions, calculations, analysis, results and conclusions in technical reports to guide product development. Designing and developing new product concepts including system level evaluation through to detailed calculation, design, testing and analysis. Supporting and trouble-shooting the introduction of new products into pilot production. On site there is extensive provision for rapid functional prototyping and testing. Their mechanical workshop includes mill, lathe, high resolution multi-material 3D printer, pick & place and dispenser robots, a polymer laser welder and CO2 laser cutter and their development lab, includes the latest instrumentation for imaging, sensing, data logging, and running automation systems. You Will have: A strong background in Engineering or Physics with extensive experience in precision, high tech, medical or engineering roles with responsibility for new product technical development. It would be desirable if the successful candidate also had experience with injection moulding, fluid dynamics, polymers and joining technologies. The successful candidate should have skills in translating product requirements into design and development objectives. They should also have good time management skills to ensure prioritisation and completion of key objectives to enable concurrent engineering. Competitive salary Opportunity to work in an innovative and creative environment Great development opportunities

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  • Senior Stem Cell Scientist 4/3/2019 12:00:00 AM

    Salary: £45000 Location: Bristol

    Bristol – Senior Stem Cell Scientist ***Company is ideally looking for Immediate Interview and Start**** Based in the Southwest of England, my client is looking to address some of the biggest global challenges facing ethical food sourcing and environmental impact. Using cutting edge, cell culture techniques, they are looking to combine biotechnological advancements and create real meat, without harming our health, planet and animals. They are currently looking for a Senior Stem Cell Scientist, to join as part of our founding team! Your responsibilities: We’re looking for senior cell scientist excited by the challenges of creating cell-based meat! As a senior scientist you will lead the cell culture development team to create robust, scalable and low-cost protocols. You will work closely with the process development team to ensure the aforementioned. You will manage the lab including writing standard operating procedures and protocols. You will work to create novel formulations of cell culture media to significantly reduce its cost. You will also work towards creating consistent animal cell lines. It is an exciting opportunity to solve complex problems regarding cell culture! You have: • PhD in cell biology, molecular biology, biochemistry or related fields • Experience with pluripotent stem cells (iPSCs preferable) • The ability to work independently in experiment design, execution and optimization • A track record in working on complex and multidisciplinary projects Salary Range: £30,000-45,000 (based on experience) Equity shares Fantastic development opportunities

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  • Senior Scientist - Cell Therapy 4/2/2019 12:00:00 AM

    Salary: £50000 Location: Oxford

    Cell Therapy Scientist – Oxford (permeant) My client is an Oxford-based biotechnology company, developing the next generation cancer immunotherapy. The company is looking for 2 motivated, cell therapy scientists, working to deliver transformative therapeutics for people with common cancers. Over the next 18 months, the focus will be developing technology for clinical trial. Working as part of the research team, you will be engaged in molecular engineering and preclinical testing of therapeutics. You will have: PhD in a life sciences subject Industry experince working to GMP/ GLP Prior background in cell therapy (such as CAR-T) Experience in performing and designing immunological assays such cell migration, polarisation, proliferation, cytotoxicity using in vitro / in vivo / ex vivo experimentation Great analytical/ data interpretation skills, with strong communication skills Diligent scientific mindset: detailed experimentation planning, execution and recording Salary: £32,000.00 to £45,000.00 (based on experience) Excellent career development

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  • Cryo-Electron Microscopy Scientist 4/2/2019 12:00:00 AM

    Salary: £0 Location: Cambridge

    My client is an international biopharmaceutical company focused on the design and development of new medicines. As a world leader in the field, the company is advancing a broad and deep pipeline of partnered and in-house drug candidates in multiple therapeutic areas including neurology, immunology, immuno-oncology, gastroenterology and rare/specialty diseases. Working in a state-of-the-art facility, the cryo-electron microscopy scientist will join their dynamic biophysics group working on GPCR structure determination to enable drug discovery efforts. What you will need • Ideally have a PhD in a relevant sciences subject • Strong theoretical understanding of cryo-EM • Have excellent communication skills and the ability to work in multi-disciplinary teams What you will do • Take responsibility for electron microscopy and associated equipment at the company, including defining best practices for instrument use, training and supervision of other users, sample preparation, and hardware and software maintenance. • Perform screening of and data-collection for samples by cryo-electron microscopy. • Collaborate with other scientists on research projects and prepare and present results (written and oral) to program teams What you will get • State of the art facilities • Highly competitive salary • Great Benefits Package This is an exceptional opportunity to participate in pioneering science with an Industry-leading Drug Discovery company. Get in touch today to ensure that you don’t miss out!

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  • Assay Development Scientist 4/2/2019 12:00:00 AM

    Salary: £0 Location: Wetherby

    My client is an industry leading life sciences company dedicated to providing Life Scientists with the high quality, unique and powerful tools they need to develop safe and novel diagnostics and treatments. Currently, the company are developing novel bio-therapeutics that will compete with monoclonal antibodies and antibody mimetics in the future of diagnostics and treatments. Due to recent expansion and growth, they are looking for a for an enthusiastic and highly skilled Assay Development Scientist with previous experience in assay development using antibodies, antibody fragments or non-antibody scaffold technologies in either the CRO or biotech sector. Working in a state-of-the-art facility, the role will be to setup and develop a range of in vitro assays (such as ELISA, cell-binding assays etc.) to support protein characterisation and the validation of their technology in industry-standard assays. What you will need • One of the following: o A BSc in a biological discipline with at least 5 years industry experience o A PhD in a biological discipline with at least 2 years industry experience • Industrial laboratory experience should be of working with and developing assays using antibodies, fragments and/or non-antibody scaffold technologies. • Be able to demonstrate a strong ability to develop target binding (e.g. ELISA, LFD, Agglutination) and phenotypic based assays (phosphorylation, cell proliferation etc.) using a range of techniques (e.g. Western blot, flow cytometry, confocal microscopy and IHC). • A bold and innovative nature and a desire to be fully involved in driving the growth of the business What you will get • State-of-the-art laboratories • Competitive Salary • Great Benefits Package This a great opportunity to be part of a dynamic team developing unique and ground-breaking bio-therapeutics. Get in touch today to ensure that you don’t miss out!

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  • Senior Systems Biology Researcher 3/26/2019 12:00:00 AM

    Salary: £0 Location: Oxford

    My client is a leading Health-Tech company that creates value from accelerating the discovery and development of new medicines and improving patient care through the analysis of real-world evidence from large databases of anonymised patient data collaboration with leading healthcare institutes. They use their proprietary clinical AI technology to analyse ethically sourced, clinically curated, anonymised patient data to solve serious unmet medical needs across a wide range of therapeutic areas, enabling a new approach to clinical trial design, drug discovery, development and post-marketing surveillance. The Role: The role will play a vital part within the Systems Medicine team and look to develop novel deep learning-based approaches to work with their EPR and linked genomics data to deliver on various projects across the drug discovery and development pathway, ranging from target ID using network biology/systems biology approaches, to patient endotype identification. This role involved using a combination of machine learning and computational biology skills to build the needed pipeline, implementing code and integration algorithms internal and client facing programs. Responsibilities: + Develop and apply topological analysis method for disease subtypes stratification and patient disease profile identification. + Build tools and approaches for integrated big data analytics using various database sources, including multi-omics data, EMR, behavioural, environmental, and imaging data. + Build drug risk models for advancing medication indication or new side effects identification. + Collaborate with team members and other scientists on analysing EMR and genomic/other omic - data. + Work with business development team for collaborating with pharmaceutical /payer to use EHR/Genomic/Phenotypic data to deliver on client projects spanning the entire drug discovery and development pathway. REQUIREMENTS: + PhD in Computer Science, Computer Engineering, Bioinformatics, or Computational Biology (MUST have). + Experience in post-graduate or healthcare/biotech/pharma experience in analysing large data sets with advanced analytics approaches. + Deep knowledge of advanced machine learning methodologies such as deep learning, graphical models, and natural language processing. Strong background in developing new algorithms and implementing algorithms from the scientific literature. + Expert experience with programming and scripting (R, Python, Java, etc.). + Experience with SQL, Oracle databases. For more information on this fantastic position please contact Robert Frame on 0161 923 8189 or robert.frame@wearenorthpoint.com

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  • Computational Biological Engineer 3/26/2019 12:00:00 AM

    Salary: £60000 Location: London

    I am currently recruiting for a company based in Camden Town, for a Computational Biological Engineer. Were moving biology from manual processes with hand held pipettes and lab books to reproducible automated experimentation, traced samples, structured datasets and cutting-edge data analysis. This is a highly collaborative effort between software developers, biologists, engineers, mathematicians, bioinformaticians, designers and our growing list of industrial partners in the biosciences. ***What the Computational Biological Engineer will do*** + This is an engineering role within computational biology, where it would also be advantageous for you to have lab-based experience or have a good understanding of how lab work is conducted (but you will not be required to do any wet-lab work). + Projects will range from engineering biological systems to optimising assays. Opportunities will also arise for managing client projects, from development to their on-site implementation, and liaising with our diverse customer-base to help support their research needs + Your past experience in hands-on research will be crucial for engaging with and understanding our needs and clients specific application needs. You will have a drive to produce high-quality deliverables, and build successful business relationships with clients + Our main current target market is the pharmaceutical sector, so relevant experience is a plus, particularly in discovery, development or analytics. In particular, we are interested in hearing from candidates with mammalian cell work experience ***What the Computational Biological Engineer will need*** + At least PhD and/or Post-Doc level experience - ideally with industry experience + Experience developing bioinformatics applications in at least two programming languages Go/Python/R/Matlab + Knowledge and/or experience of hands-on lab work + Experience with abstracting scientific concepts in computational space ***What the Computational Biological Engineer will get*** + Excellent salary up to £60,000 + Very good benefits package + Experience working with some truly ground-breaking engineers & Scientists If this role sounds perfect for you, then get in touch today!

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  • Computational Biologist 3/21/2019 12:00:00 AM

    Salary: £0 Location: Oxford

    I am currently recruiting for a company based in Oxford, and they are looking for a Computational Biologist with a flair for AI/ML. Having two sides to this business, they have the product side which builds digital health products / systems to help provide early detection / provide self-management help for patients. Then they have the other side, where the NHS provides them with anonymised patient data so they can use this for research purposes. They are building AI into these databases to be able to answer questions for large pharmaceutical companies, so that they can improve drugs and discover new medicines based on real patient data. ***What the Computational Biologist will do*** I am looking for a highly-motivated Senior Data Scientist/Bioinformatician to lead projects that will develop and deliver cutting edge therapies and biomarkers to benefit patients + The ideal candidate must demonstrate proven experience in leading independent research projects at the interface between biology, informatics, genetics and/or medicine + position requires combining an in-depth understanding of biological sciences with computational techniques in statistics and mathematics, and the ability to identify novel research opportunities and carrying them out independently and successfully + Develop, maintain, and utilize cutting-edge pipelines for the processing and analysis of high-throughput data to drive biological insights + Integrate ‘omics data and collaboratively leverage large-scale data mining of public and private resources to support biomarker and target discovery aims ***What the Computational Biologist need*** + Proficient in SQL, R and Python is a prerequisite, and demonstrated Linux/Unix scripting competency. + Demonstrated strong knowledge of NGS analysis & Statistics/ Data Modelling + Ph.D. and/or M.Sc. in a biology, genetics or a computer science field + Experience within open source development environments ***What the Computational Biologist will get*** + Excellent salary entirely dependant on experience + Very good benefits package + Experience working with some truly ground-breaking engineers & Scientists If this role sounds perfect for you, then get in touch today!

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  • Lead Bio-Process Engineer 3/18/2019 12:00:00 AM

    Salary: £0 Location: Bristol

    Based in the Southwest of England, my client is looking to address some of the biggest global challenges facing ethical food sourcing and environmental impact. Using cutting edge cell culture techniques, they are looking to combine biotechnological advancements and create real meat without harming our health, planet and animals They are currently looking for a passionate and driven process engineer, with experience in cell/gene therapy technology development or engineering, to join their founding team! If you’re skilled, passionate, dedicated and looking for a role that can make an impact, this may be the role for you! Your responsibilities: As an engineer, passionate about process development and excited to scale up cell-based meat, you will oversee the modelling of processes and scale up to pilot plant. You will be responsible for designing and execute experiments in bioreactors including process and media optimisation, developing planning and co-ordinating projects and continuously improving on project execution. You will work closely with the rest of our founding team, advisors and partners to ensure that the R&D work is robust and scalable. You have: • +3 years within process development or cell/gene therapy technology development/engineering. • MSc, M.Eng or higher in Chemical Engineering / Bioengineering or another relevant subject • Experience in designing and operating bioreactors • Stem cell/mammalian cells bioprocessing experience • Comfortable developing PFD, P&IDs, mechanical designs, HAZOP and SOPs • Understanding of GMP and relevant ISOs • Experience with computer simulations Competitive salary: (based on experience) Excellent career opportunities

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