Biotechnology

  • Senior Viral Vector Scientist 10/23/2018 12:00:00 AM

    Salary: £46000 Location: London

    The Client My client, based in London, are specialists in helping Cell and Gene therapy companies translate early stage research into quality, commercially viable, scalable and investable therapies. With a team of over 120 Cell and Gene therapy experts and state-of-the-art development and viral vector labs, my client has ensured they remain a Centre of Excellence in this field. Purpose of Role: The purpose of this role is to provide expertise in the execution of viral vector industrialisation projects. The viral vector strategy will focus on the use of industrial bioprocessing techniques such as bioreactors and chromatography, to ensure supply of these critical materials for in vivo and ex vivo cell therapies. Key Accountabilities: Delivery of viral vector process and analytical development projects through technical oversight of project, working with the Lead Scientist on experimental design and execution. Particular focus upon downstream process operations, including unit operations from harvest to final fill Assist with costing of proposals for partners and support of BD function during new project scoping by providing technical support activities. Strong interaction with the Tech Transfer function and Project Managers to enable the development and tech transfer of viral vector processes. Strong Interaction with academic and industry based groups to provide engineering solutions for vector cell line development, upstream and downstream bioprocessing Generating manufacturing and development protocols in relation in vivo and ex vivo gene therapy products to support technology development and regulatory submissions Author GM Risk Assessments when requested and support GMSO. Maintain general laboratory cleanliness, Health and Safety and GXP standards, where appropriate Experience Experience of upstream and downstream bioprocessing of viral vectors including viral vector biology and cell line development. Experience or know how of working with GMP regulations to manufacture viral vectors, cell therapies or other biologics. Experience of cell culture of human and/or mammalian cell lines is essential. Experience in the development of analytical assays suitable for use as characterisation, QC release methods and in-process controls is desirable. Experience of tech transfer to/from commercial and research organisations Experience of viral vectors used in the ex vivo and in vivo modification of products is essential. Experience of working closely with BD and partners to plan, cost and secure projects. Experience in QMS is highly desirable. Experience in writing and carrying out GMP production protocols is desirable. Experience of delivering on agreed commercial objectives For more information please contact Robert Frame on: robert.frame@wearenorthpoint.co.uk or 0161 504 8058

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  • Lentiviral Vector Scientist 10/17/2018 12:00:00 AM

    Salary: £38000 Location: Oxford

    My client is a leading gene engineering company who are pioneering technologies that streamline the biopharmaceutical design, discovery and development process of viral solutions, gene editing solutions and antibody solutions. My client is looking to add talented scientists to their lentiviral vector group as they look to build their expertise over the next 12 months in the viral therpaeutics field. CRITERIA: • BSc/MSc in Biology, Biochemistry, Genetics or related field, with >2 years relevant experience or Ph.D with >1 year relevant experience • Experience working in a commercial/industry environment is preferred but not essential. Essential: • Extensive track record of handling a range of adherent and suspension mammalian cell lines. • Knowledge and experience of viral vector engineering, production and characterisation, with a focus on Lentivirus. • Good experience with analytical techniques including flow cytometry and qPCR. • Ability to independently analyse, interpret and present scientific data in a clear manner. • Good communication and inter-personal skills. • Strong ability to multi-task under pressure. For more information on the above position, please contact Robert Frame on 0161 504 8058 or robert.frame@wearenorthpoint.co.uk

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  • Protein Engineering Scientists (Oncology)- All Levels 10/11/2018 12:00:00 AM

    Salary: £48000 Location: Abingdon

    Protein Engineering Scientist(s), Oncology We are looking for dedicated scientists, both senior and junior, to expand and strengthen our oncology protein engineering team. We are on the hunt for pragmatic, open-minded and collaborative bench scientists who are looking to contribute and grow in an open, team-oriented environment. Associate Scientist: £21,000- £31,000 Scientist £27,000 - £39,000 Senior Scientist: £33,000 - £48,000 As a member of our Protein Science team you will be responsible for: TCR and ImmTAC expression in E.coli, refolding and purification using chromatography methods Analysing TCR and ImmTAC binding affinity and kinetics Identifying TCRs from internally-generated phage libraries Enhancing TCR affinity using our proprietary phage-display approach Collaborating cross-functionally to develop and optimize ImmTAC drug candidates Analysing and reporting experimental results verbally and in writing To succeed in this role, you should have technical proficiency in the areas of protein biochemistry and molecular biology. Essential skills include: protein expression in E.coli, chromatography-based protein purification (preferably using the AKTA system), SDS-PAGE, PCR, cloning, DNA sequence analysis and site-directed mutagenesis Desirable skills include: DNA library construction/screening using phage display and analysis of protein interaction using BIAcore and Octet systems You should have an advanced scientific degree, such as MSc or PhD in protein engineering/ biochemistry/ molecular biology or a related discipline. This is an exciting time to join one of the UK’s leading biotechnology companies. We look forward to hearing from you! Please note, sponsorship is not available for this role

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  • Molecular Biology - AAV Scientist 10/10/2018 12:00:00 AM

    Salary: £38000 Location: Oxford

    My client is a leading gene engineering company who are pioneering technologies that streamline the biopharmaceutical design, discovery and development process of viral solutions, gene editing solutions and antibody solutions. As my client intends to further build its expertise over the next 6 months in the viral therapeutics field they are looking to add a molecular biologist to their team who will work across a range of internal and commercial projects, focusing on the generation of molecular constructs for the production of Adeno-associated virus. The role will work closely with the AAV production team and sits within the AAV Vector Group, which addresses both viral vector engineering and novel-bioproduction methodologies. CRITERIA: • BSc/MSc in Biology, Biochemistry, Genetics or related field, with >2 years relevant experience or Ph.D with >1 year relevant experience. Essential: • Practical experience of molecular biology techniques, including ligations, restriction digestion, PCR, DNA sequencing, RT-PCR and ELISA. • Experience with cell culture is preferred. • Prior experience in generating complex DNA constructs. • Ability to independently analyse, interpret and present scientific data in a clear manner. • Good communication and inter-personal skills. • Strong ability to multi-task under pressure. Desirable: • High-level knowledge of AAV genetics, and gene therapy applications. • Track record of handling adherent cell lines in multiple formats (multiwell plates, hyperflasks/stacks, cell factories). • Handling and transfection of suspension cell lines. • Analytical techniques for genetic characterisation of viral particles

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  • Gene Editing Product Development Manager 10/10/2018 12:00:00 AM

    Salary: £0 Location: Norwich

    Product Development Manager - Norfolk- Permanent Based in Norfolk and London, my client is a global leader in advanced agronomic technologies. Due to a fantastic period of growth at the Norfolk site, they are looking for an experienced Product Development Manager, to collaborate with their research team in the R&D and later commercialization, of cutting-edge gene-editing-based enabling technology products. Your primary roles will be to guide and oversee the development of our advanced gene editing tools and support their global commercialisation in the life-sciences industries (Incl. the Agribusiness and Pharma sector). You will be involved in the development projects at all phases of the pipeline from initial design to sales, and should feel comfortable working in a fast pace, dynamic work environment. The successful candidate will have: ? MSc or PhD degree in relevant technological subject (e.g. Sciences, Engineering). ? 3+ years’ experience in project/product management in the life-sciences or agribusiness sectors. ? Proven experience in collaborating with development teams to accomplish defined goals in a timely manner. Competitive salary (based on experience) Excellent development options Full time position

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  • Bioinformatician 10/10/2018 12:00:00 AM

    Salary: £0 Location: Norwich

    Bioinformatician- Norfolk- Permanent Based in Norfolk and London, my client is a global leader in advanced agronomic technologies. Due to a fantastic period of growth at the Norfolk site, they are looking for an experienced bioinformatician to help develop novel genome editing platforms and product pipelines. Your primary role will be to identify, invent, develop and implement computational biology methods to support the development of gene editing based technology and products. Spanning areas such as host/pathogen analysis, disease indications, sequence analysis, comparative genomics, pathways, networks, gene and regulatory RNA expression; you must be comfortable working in a dynamic, fast changing environment, and be able to communicate complex biological mechanisms, methods, analyses and results to scientists from diverse backgrounds. The successful candidate will have: ? Ph.D. degree in Bioinformatics-related subject, preferably with 3-5 years postdoc and/or industry experience (MSc with extensive experience will be considered) ? Experience in developing automated pipelines, mining large-scale genomic and RNA datasets, developing custom analysis tools and establishing internal repository data resources ? Plant genomics background Competitive salary (based on experience) Excellent development options Full time position

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  • Technology Development Scientist 10/2/2018 12:00:00 AM

    Salary: £0 Location: Oxford

    I have an incredible opportunity to join a Teal organisation who are pioneering the latest and greatest Super-Resolution Fluorescent Microscopes. My client has made huge waves in the industry and were founded on the back of Nobel Prize winning research. They’re now looking to grow their company and have a number of exciting opportunities for those who are ready and capable of joining a multi-disciplinary team, working with autonomy and confidence. I am looking for an ambitious, organised and hardworking molecular biologists or biochemists to develop single-molecule applications - novel biochemical methods to work with my clients state-of-the-art microscopy system. You will be part of a nascent research activity, imagining, creating and following through on clever new ideas. You will be responsible for designing, performing and analysing new assays that use the microscope in clever ways to explore biological samples of interest. Having complete accountability day-to-day for setting up, organizing and performing experiments, as well as analysing, organising and reporting on the data produced and participating in team meetings, strategy discussions and journal clubs. If you want to join a team who are literally changing the way in which we see the world, this could be the opportunity for you. For more information and a confidential discussion, please contact me on: - Tel: 0161 923 8174 Email: kieran.whttaker@wearenorthpoint.co.uk

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  • Senior Application Scientist 9/24/2018 12:00:00 AM

    Salary: £50000 Location: Church stretton

    Senior Application Scientist- Shropshire- Excellent Salary (Company are looking to hold phone conversations asap) Based in Shropshire, my client is one of the leading manufactures of diagnostics products for the Chemical Pharmaceutical and Life Science industries. Due to continued growth, a fantastic new opportunity has arisen for a Senior Application Scientist, to join our small but highly specialised team, focused on the Immunodiagnostics industry This is a challenging and diverse role requiring the ideally candidate to have a proactive and positive approach to problem solving as well as working both autonomously and as part of a team, leading projects. The position requires both a strong commercial awareness and the technical ability to understand customer needs and translate these into all aspects of new product development and support for the existing portfolio. This role will be split 50% in the lab and 50% commercial and marketing activities. You will have: BSc or higher with a focus in chemistry. Life sciences or bioengineering. 5 years industry experience or 2 years in direct product management A firm understanding of immunodiagnostics/ immunoassays (an understanding of magnetic bead and latex particles design, specification, characterization and analysis for use in diagnostic applications would be advantageous). Ability to travel worldwide as required up to 10-20% of the time. Right to work in the UK/EU Salary between £45-£50,000 (dependant on experience) Great benefits Excellent career oppurtunities

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  • Molecular Biologist / Strain Engineer 9/18/2018 12:00:00 AM

    Salary: £0 Location: Bedford

    Im working with a great company poised to change the world. Theyre currently looking for someone with experience in Molecular Biology, with a preference towards Strain Engineering. If you also have experience in 'omics' or with NGS/High-Throughput Screening, you are the Unicorn I need. The company specialise in finding novel solutions to some of the leading problems we face in the world, ranging from developing medicines, to reducing environmental damage and also discovering new Bio-technologies. This position is perfect for someone who loves to tinker, for someone who looks at life differently and wants to build a brighter, more environmentally conscious world. Im only able to consider those with a Ph.D for this opportunity. If this is you, what are you waiting for, send me a message?! ;)

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  • Computational Biologist 9/4/2018 12:00:00 AM

    Salary: £0 Location: Kidlington

    I am looking for a Computational Biologist, this person will be based in a state-of-the-art facility in Oxford. They will be working in the computational biology group as part of the team responsible for developing, testing and maintaining data analysis workflows used both internally and customers of the next-generation sequencing products business. The main responsibilities will include developing new analysis workflows/pipelines by writing clean code, coupled with clear documentation and rigorous testing that are used internally and integrated within the Computational Biology NGS software product range. The Data Analysis team also liaises directly with customers and other stakeholders to answer any analytical questions and related support, so strong written and verbal communication skills are essential. ***What the Computational Biologist will need*** + Education to degree level in a related field + Experience working in a computational and data analysis environment + Strong programming skills in Java, Perl, Python or R + An understanding of Linux based environments + Some SQL knowledge ***What the Computational Biologist will get*** + Competitive salary £££ + Excellent training and progression opportunities + The chance to work in a ground break field of Science If this role sounds perfect for you, then please get in touch today!

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