Biotechnology

  • Senior Scientist Phage Selections 7/16/2018 12:00:00 AM

    Salary: £45000 Location: Cambridge

    Based in Cambridge my client is a market leader in bio-therapeutics. Due to continued growth the company are looking to develop a new pipeline of products targeted to oncology and inflammatory diseases and are looking for Senior Scientist in Phage Selections to join their team. You will be responsible for designing and carrying out phage display selections, screening and characterisation of outputs in order to identify lead Affimer therapeutic candidates. You will have: Essential skills and previous experience •MSc or higher in protein biochemistry/molecular biology with a minimum of 2-4 years’ laboratory experience or equivalent. •A minimum of 2 years’ laboratory experience of working in the field of in vitro display technologies (one or more of phage display, ribosome display, yeast display etc.) •A high level of lab-based competency in molecular biology, manipulating DNA and creating expression constructs. •Experience of characterising protein-protein interactions using at least two of the following methods; ELISA, HTRF, cell-based assays, SPR or BLI Salary from £30,000- £50,000 depending on experience Fantastic career opportunities State of the art facilities

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  • Research UPS Scientist 7/13/2018 12:00:00 AM

    Salary: £30000 Location: Cambridge

    My client is a leading biotechnology company developing novel drugs for the treatment of bacterial infections, to address the serious issue of increased antibiotic resistance worldwide. Due to current expansion they are currently hiring for a research upstream scientist to join the team, with a working knowledge and practical experience with cell cultures and cell banking. Your duties will be mainly lab based however the key duties and responsibilities are as follows: 1. Design, develop and optimise bacterial fermentation processes suitable for manufacturing. 2. Work with production methods such as shake flasks, 1L Glass bioreactors up to 15L scale stainless steel fermentation systems. 3. Ensure laboratory notebooks and/or Batch Manufacturing Records are completed and maintained according to Standard Operating Procedures (SOP). 4. To form part of multidisciplinary teams working within all areas of the Process Development team, and provide results, data and progress to project leaders. Role requirements: To be successful in your application we are looking to identify the following on your profile: 1. Master’s degree and extensive laboratory experience in a Life Science discipline such as Biochemistry, Biotechnology, Biochemical Engineering etc. as well as experience of working to GMP in a biopharmaceutical environment. 2. Proven industry experience in developing and/or optimising methods for biopharmaceutical manufacturing. 3. A working knowledge and practical experience with cell culture and cell banking.

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  • Quality Assurance Officer 7/11/2018 12:00:00 AM

    Salary: £25000 Location: Bradford

    Based in Bradford though with 9 other locations across the UK, my client is a knowledge based, science led business focused on delivering the expertise and capabilities their clients demand. They work in the pharmaceutical, biotechnology, food, environmental, agrochemical, petrochemical, chemical and consumer products sectors. They currently employ over 700 people across all locations in the UK. They are currently expanding and are looking for an experienced QA officer looking to further their career. The Quality Assurance Officer’s function is the independent GLP monitoring of work. As the Bradford site conducts work to Good Manufacturing Practices Regulations this role will have the opportunity to cross train in GMP auditing. Candidates should have the majority of the following skills; + BSc in Chemistry or related scientific subject + Substantial working experience of GLP auditing. + Consideration will be given to applicants with less auditing experience who have worked in a Regulatory GLP environment. + The GLP regulations and principles experience we are looking for in this position are UK SI 1999 No. 3106: The GLP Regulations & OECD GLP Principles. Salaries are expected to be between 20-25k dependent on experience. In addition the company offer a range of learning and development opportunities depending on the role, with all employees having access to a range of internally delivered training modules as standard. They offer as a minimum: Pension scheme, Healthcare Cash Plan, Retail Discount scheme, Cycle to Work scheme, Childcare Vouchers, Discounted Gym membership rates and local Reward & Recognition schemes.

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  • Senior Data Scientist 6/15/2018 12:00:00 AM

    Salary: £100000 Location: Hasselt

    Based in Belgium our client are a small but cuttiong edge company based from offices in Hasselt in Belgium. They were formed 4 years ago, and offer machine learning solutions to the PCR analysis market; allowing companies to interpret PCR data at a higher accuracy, and decreased time compared to historical methods. As a data scientist, you will create the little pieces of intelligence that are plugged into the clients PCR workflow software platform. These so-called plugins are the beating heart of our product and consist of machine learned algorithms, specific molecular diagnostic information, and client-specific logic. You will focus on algorithm development, applying the latest machine learning techniques to interpret our biomedical data automatically. Besides that, you could take up a dataOps role. You optimize our process, spot efficiency gains and increase our throughput. The companies product is situated on the challenging crossroad between IT and biotechnology, directly aimed at laboratories and diagnostic test manufacturers within clinical, agricultural, companion, livestock & other diagnostics. We’re on a mission to improve the way data is analysed and are already working with industry-leading companies. Ideal candidates will have; + A master/ PhD degree in mathematical engineering and or computer science and you love data, especially lots of it. + You speak Matlab, a background in Python and/ or R is a plus. + You have a broad background and interest in all different techniques in artificial intelligence, you are experienced in using this knowledge to solve concrete business needs. + You are an expert when it comes to artificial intelligence and machine-learning. + You are familiar with or an expert in signal processing techniques. Our client have a stimulating startup atmosphere where you can grow your capabilities in an open and no-nonsense company culture. They want you to do the work you feel great at, or that you would like to become great at. They offer a fascinating role with continuous learning in an international environment where you will have the possibility to grow and shape a software solution right from the start. They combine state of the art data science with cutting edge technology in a streamlined development process to ensure we deliver only the best solutions to our customers. Salaries for the role are dependent on experience but are expected to be between 50-100k for the right candidates.

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  • Technical Manager - Sterile Processing 6/15/2018 12:00:00 AM

    Salary: £61000 Location: Oxford

    My Client is a leading gene and cell therapy company focused on developing life changing treatments for serious diseases. The client has undergone recent expansion and is currently hiring an experienced Technical Manager. They will provide both technical and scientific leadership within the department along with developing and maintaining relationships with key suppliers and technology providers. My Client is looking for an experienced Technical manager who has worked within a GMP environment and can support the activities within the MSAT function. The role will undertake and focus around sterile and aseptic processing for both third party clinical and commercial sterile manufacturing activities. . Key responsibilities and accountabilities: ? Provide technical and scientific leadership within OXB on aseptic processing and fill/finish activities for clinical and commercial manufacturing including technology transfer, technical troubleshooting, and continuous improvement of sterility assurance. ? Act as Subject Matter Expert (SME) utilising your technical competence and knowledge in aseptic processing, fill-finish, inspection and packaging to provide guidance on best practices to improve aseptic processes and procedures and maintain regulatory compliance. ? Generate and review documentation supporting technology transfer and New Product Introductions (NPI). Define appropriate success criteria for technical transfer and provide/document evaluation of the technical outcomes. ? Provide subject matter expertise (SME) within OXB on clean room technologies, single use systems and raw materials, design of process simulations (media fills), sterile manufacture. ? Extensive knowledge of the design, validation, operation and maintenance of the controlled environment including clean rooms, isolators, RABs, sterilisation processes, environmental monitoring and routine disinfection. Experience of manual and automated fill finish operations would be ideal. ? Experience in preparation for and participation in inspections (including FDA & MHRA) as well as performing focused GMP audits of sterile facilities. Person Specification: ? Bachelor degree (Masters/PhD/EngD preferred) or equivalent experience in a relevant science (e.g. Biological Sciences, Microbiology,) with substantial relevant experience in an industrial setting ? At least several years’ experience of working in multiple aseptic or sterile manufacturing facilities Salary: £56,000 - £61,000 This is a unique opportunity to join an ever-growing, organisation. Contact Robert Frame at NorthPoint Recruitment for immediate application.

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  • Upstream Scientist 6/13/2018 12:00:00 AM

    Salary: £38000 Location: Oxford

    Our client is a leading biopharmaceuticals organisation based from state-of-the-art offices in Oxford. Having rapidly expanded over the course of the last 3 years to over 300 employees, they are currently recruiting a wide range of biotechnology based positions. The company are at the forefront of the gene and cell therapy sector, having built a novel drug development platform which they leverage to develop products both in-house and with partners. Their proprietary portfolio of products include a lead product for Parkinson’s disease. With preparations completed for this to move into the clinic, they are in active discussions with a number of third parties to potentially out-licence the product, thereby sharing the costs and the risks whilst retaining an interest in the value of the product as it progresses. Other products at development stage include a gene-based therapies for corneal graft rejection and cancer. The company have a very respected name in the industry, and offer potential candidates a strong career path, generous financial renumeration, and a caring yet focussed environment in which to flourish. We are currently helping to resource for their upstream fermentaiton needs within their Process, R & D team. + To optimize upstream processes for producing lentiviral vectors, working within the Process R&D group. + Small scale and laboratory scale bioreactor cell culture activities for scale-up/scale-down of existing bioprocesses + Applying DoE methods to cell culture activities. PR&D works with the clients research teams involved in vector and cell engineering to ensure the seamless transfer of processes from research to manufacturing. The scope of work may include, but are not limited to vector purification, novel purifications, purification process development and verification, technology assessment, data analysis and project reporting. The individual must have a demonstrated ability to work independently and to manage multiple projects either through direct supervision or in collaboration with the programme team. The individual must be innovative and creative, show initiative, collaborative ability and have good general science management skills. Applicants are expected to have excellent time management skills, with the ability to adapt to rapid changes in projects priorities and meeting aggressive timelines. The individual should also enjoy working in a team setting and be able to work well with both research scientists and as well as external collaborators. Salaries for the position are expected to be in the 35-38k range.

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  • Deep Learning Researcher 6/12/2018 12:00:00 AM

    Salary: £45000 Location: Oxford

    Based in Oxford, my client are a leading medical imaging technlology company who are looking for a first-class medical imaging researcher to join their technology team, developing cutting-edge image processing and deep learning algorithms to improve acute stroke diagnosis. You will take a leading role in researching the fundamental science and algorithms that contribute to the company’s core IP. This is an exciting opportunity to bring the latest medical imaging research into real-world use. You must have an excellent understanding of state of the art medical imaging technology, with a PhD in a relevant research area, or otherwise demonstrate outstanding research ability. Recent work with contrast and non-contrast CT, or MRI image analysis would be particularly desirable, especially in brain imaging or stroke-related fields. Other skills we are looking for include: + A good core knowledge of computer vision and image processing algorithms, particularly filtering, image registration and classification techniques. + Experience with developing deep learning algorithms for image analysis + Active participation in the medical imaging research community + Programming expertise in Python + An ability to clearly communicate complex ideas and systems, both to technical colleagues (e.g. software developers) and non-technical audiences, both verbally and through graphical or textual content + An ability to generate creative ideas and solutions to real-world problems, based on a deep understanding of the problem domain + Data science skills, including data preparation, cleaning, and scripting You will be given a significant share of responsibility for the underlying technology behind my clients products, and you should be able to work independently on complex problems. However, team members are expected to work together to find elegant solutions to issues from all areas of the company, so clear communication is vital.

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  • Senior / Principal / Lead MSAT Scientist. Contract 6/12/2018 12:00:00 AM

    Salary: £0 Location: Oxford

    Senior/Principal /Technical Lead Scientist/Engineer (MSAT). Contract. Oxford My client, a globally renowned Gene Therapy are under going a phase of expansion. As part of this, they require support in Manufacturing Sciences and Technology team. There are currently 3 open positions for Contract MSAT Scientists/Engineers. Company and Team Overview An exceptional company with over 20 years’ experience in Gene and Cell therapy. True pioneers in the field, they were the first organisation to treat humans through in vivo lentiviral based vectors. This MSAT team is involved in all aspects of clinical and commercial manufacturing carried out either in-house or by third party CMO’s on behalf of the company. Job Overview ? Provide technical and scientific leadership to clinical and commercial manufacturing on-site and third party CMO sites including technology transfer, technical troubleshooting, complex deviation investigations, change control, and continuous improvement. ? Perform root cause investigations using a systematic approach to resolve complex problems and lead multidisciplinary teams in developing and implementing solutions. ? Gather, evaluate and analyse complex process data for all products and sites for manufacturing process robustness and capability via ongoing process verification. ? Partnering with other functions to ensure scale-up is robust and scientifically sound leading to consistent performance Key Responsibilities and Accountabilities ? The successful candidate will be an influential MSAT representative within the organisation working across multiple projects at different stages of the commercial lifecycle. ? Lead cross-functional activities working across Research, Process R&D, Manufacturing, Supply Chain and Quality Groups. ? Technical reviewer of manufacturing documentation (batch manufacturing records, deviation handling, CAPA, change controls, SOPs, etc.) ? Responsible for internal documentation to ensure quality and compliance required for regulatory submissions. ? Generate and review documentation supporting technology transfer and NPI. Define success criteria for technical transfer and provide expert evaluation of the technical outcomes. ? Help to build and maintain a process-specific knowledge database for technology transfer, NPI and process stewardship; identify continuous improvement activities to improve performance. ? Develop relationships with suppliers and service providers ? Provide guidance on process transfer and support activities to junior members of the team. Key Skills and Requirements ? Process development or GMP production experience preferred. ? Experience in aseptic processing and/or fill & finish would be an advantage. ? Proven influencing skills at all levels of the company across multiple project teams. ? As a person in plant, provide technical support and training of manufacturing personnel to improve understanding of cell culture, purification and fill & finish operations across the manufacturing sites. ? Expertise in the use / application of variety of problem solving tools and quality risk assessment methodologies would be ideal. *Travel may be required in support of tech transfer activities. Person Specification ? Minimum post-graduate degree in Biology/Biochemistry, Chemical/Biochemical Engineering or a related field with a minimum of 5+ years of industrial experience. ? Alternatively, a candidate with extensive industrial experience in Biologics (7 years+), ideally within a GMP regulated environment. ? Demonstrated interpersonal skills with ability to work cross-functionally both with internal and external partners. ? Excellent communication skills to gain internal company support and influence external CMOs at all levels. ? Good time management and experience of dealing with conflicting priorities and multiple tasks. ? An interest in operational excellence is desirable. ? Knowledge of Microsoft Office Suite is required; preferably with data base development experience. ? Experience in process automation and software solutions would also be an advantage. The Package The successful candidates can expect a generous hourly rate and significant length of contract. In addition, this is an excellent opportunity to join a real player in the Gene Therapy sector and a chance to gain referrals, recommendations and build reputation.

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  • Scientist (Bioinformatics – Genome Editing) 6/11/2018 12:00:00 AM

    Salary: £38000 Location: Oxford

    My client, a leader in synthetic biology, is a specialised contract research organisation offering services to support the discovery, development and production of biologics, with a particular focus on viral vectors for gene therapy applications. A unifying theme across the portfolio is expertise in DNA design, expression system optimisation, cell line development and engineering of viral delivery systems. They are located within purpose-fitted laboratories at the Oxford Science Park, just South of Oxford. They are in a phase of rapid expansion and are seeking highly motivated and enthusiastic scientists and engineers to join the team and help facilitate the next stage of their development as a company. My client seeks an enthusiastic and self-starting bioinformatician to design, implement and evaluate novel software tools to support their genome editing group. In particular, the successful applicant will train machine learning models to predict the targeting patterns of CRISPR/Cas9 gRNAs. The successful applicant will join their interdisciplinary bioinformatics team, working alongside scientific programmers, infrastructure engineers, and web app developers to support both commercial and R&D projects. No prior experience of working with CRISPR/Cas9 is needed. Key Responsibilities + Work with the genome editing team and NGS specialists to develop a framework for reliably evaluating the targeting patterns of CRISPR/Cas9 gRNA libraries. + Apply state-of-the-art data science and statistical learning techniques to derive gRNA suitability/fitness rule-sets from the in-house CRISPR/Cas9 NGS datasets. + Engineer user-friendly software tools to facilitate CRISPR/Cas9 gRNA library design against new targets; work closely with the in-house software engineers to integrate interfaces for these into the web-based LIMS. + Stay up-to-date with new developments, technologies and methods in genome editing, and proactively seek out collaborations with their group leaders to develop and extend our intellectual property portfolio in this area. + Carry out any other duties commensurate with the grading of this post, as required. Salary is negotiable on experience.

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  • Validation Manager 6/11/2018 12:00:00 AM

    Salary: £65000 Location: OXFORD

    Validation Manager (permanent)- Oxford- Biotech- up to £65k Based in Oxfordshire, my client is a world leader in Gene and Cell Therapy technologies. Due to a fantastic period of growth they have an exciting opportunity for a motivated individual to join and lead the validation department as a Validation Manager. You will be responsible for acting as the subject matter expert and supporting the GMP manufacturing facilities by managing and coordinating all aspects of validation (equipment & facilities qualification and routine requalification activities, cleaning validation, computerised systems validation and process validation) and overseeing the Validation Team. Key skills and requirements: You will have: BSc in life sciences or another relevant subject Significant validation experience within a GMP environment Valid UK Driving License Significant team management experience. Proven problem-solving skills/diagnosing faults/resolving qualification issues. Competitive Salary Fantastic development opportunities Great Career progression

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