Biotechnology

  • Research Associate/Senior Research Associate, Phage Selections 11/27/2018 12:00:00 AM

    Salary: £0 Location: Cambridge

    Based in Cambridge my client is a market leader in the next generation of biotherapeutics. Due to a fantastic period of growth, they are looking to take on, two new Researchers at either Associate or Senior Research Associate level. This position will be a lab based, hands-on role, working as part of a small dynamic team. You will be responsible for to carrying out phage display selections, screening and characterisation of outputs via a variety of methods. You will have (Essential): A BSc or higher in biology, biochemistry, molecular biology, biotechnology or similar Previous practical experience of working in a laboratory Desirable: Experience manipulating DNA and/or creating expression constructs A good understanding of characterising protein-protein interactions by ELISA (experience of HTRF, cell binding assays and SPR/BLI would be a particular advantage) Experience of recombinant E.coli expression systems, protein purification and characterisation Competitive salary Great company culture State of the art facility

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  • Senior Scientist Microbiology 11/20/2018 12:00:00 AM

    Salary: £0 Location: Aberdeen

    I am currently working with a leading pharmaceutical company who are pioneering a new class of revolutionary biotherapeutic medicines. Due to continued success and a robust product pipeline they are now recruiting for a number of positions. This role will primarily perform testing required to support the core research and development program of the Discovery I Micro team. The primary focus of the Discovery 1 Micro team is to carry out high-throughput and secondary screening of the propriety strain library to identify candidate LBPs capable of modulating host-microbe interactions. The Research Scientist is required to make scientific observations, maintain detailed workbooks/documentation and ensure all documentation fulfils generally accepted professional/industry standards. The Research scientist will be expected to propose new screening strategies and introduce and validate new screening approaches/methods ensuring they are current and compliant with industry standards and regulations. Requirements also include maintaining a thorough understanding of my client’s services, technical principles and applications. Proficiency in running a variety of assays and molecular techniques are required along with independent and flexible working. The post holder will also be responsible for writing reports and SOPs, contributing to writing papers and present findings at internal and external meetings. If you have a strong microbiological background, experience working with human bacteria, anaerobic cells, leading or supervising a team and a want to work with a company who are truly revolutionising the way in which we treat some of the world’s most tenacious diseases, then this could be the opportunity for you. For more information please contact Kieran Whittaker for a confidential discussion on: Email: Kieran.whittaker@wearenorthpoint.com Phone: 0161 923 8174

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  • Senior Research Scientist (Disco II) 11/20/2018 12:00:00 AM

    Salary: £0 Location: Aberdeen

    I am currently working with a leading pharmaceutical company who are pioneering a new class of revolutionary biotherapeutic medicines. Due to continued success and a robust product pipeline they are now recruiting for a number of positions. This role will primarily provide scientific expertise to the activities of the Discovery II Host team. The primary focus of the team is to investigate the mechanisms behind the host-microbe interactions of their preclinical LBP candidates. Proficiency in running a variety of cellular and molecular techniques is required along with independent and flexible working. The post-holder will also be responsible for writing reports and SOPs, contributing to writing papers, present at internal and external meetings. If you have a strong immunological background, experience leading or supervising a team and a want to work with a company who are truly revolutionising the way in which we treat some of the world’s most tenacious diseases, then this could be the opportunity for you. For more information please contact Kieran Whittaker for a confidential discussion on: Email: Kieran.whittaker@wearenorthpoint.com Phone: 0161 923 8174

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  • Associate Director Bioinformatics 11/7/2018 12:00:00 AM

    Salary: £0 Location: Cambridge

    Associate Director of Bioinformatics -Cambridge- Permanent Based in Cambridge my client is a specialist therapeutics company, focused on the discovery and development of novel antibiotics. Due to a fantastic period of growth they are looking for an experienced Associate Director of Bioinformatics, to work within their R&D group. The ideal candidate will have expertise in bioinformatics drug discovery support and management, ideally including experience in antibiotic discovery. The role will involve the processing, analysis and interpretation of data to provide input for multiple drug discovery programmes. You will also help evolve the company’s proprietary analysis tools, in order to drive the future of the business. This will include driving the company’s biological and strategic applications as well as being a hands-on leader. You will have: Minimum of a BSc or higher in Bioinformatics, Microbiology, Molecular Biology or another relevant subject. Minimum of 3 years’ experience of leading program support within pharma or biotech, preferably with antibiotic experience. Must have strong project management and leadership skills. Have practical experience in interpreting genome-wide data with good knowledge of genome sequence assembly, sequence mining and biochemical pathway mapping Experience in translating genomic outputs to biochemical and preferably microbiological understanding Experience with UNIX systems, along with a couple of relevant programming and scripting languages (e.g. Python, Perl, Java, etc.), is preferred Competitive salary (dependant on experience) Excellent development opportunities

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  • Bioinformatician 11/7/2018 12:00:00 AM

    Salary: £0 Location: Cambridge

    Bioinformatician-Cambridge- Permanent Based in Cambridge my client is a specialist therapeutics company, focused on the discovery and development of novel antibiotics. Due to a fantastic period of growth they are looking for an experienced bioinformatician, to work within their R&D group. The ideal candidate will have expertise in bioinformatic, drug discovery support and management, ideally including experience in antibiotic discovery. You will have: Minimum of a BSc or higher in Bioinformatics, Microbiology, Molecular Biology or another relevant subject Experience of working with NGS Experience with UNIX systems, along with a couple of relevant programming and scripting languages (e.g. Python, Perl, Java, etc.), is preferred Competitive salary (dependant on experience) Excellent development opportunities

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  • Research Associate/Fellow 11/1/2018 12:00:00 AM

    Salary: £32000 Location: Nottingham

    1-year FTC/ rolling contract: Immediate start Based in Nottingham, my client is looking for a Research Associate with experience in phage display. Working as part of a small team you will be focused on the development and application of novel molecular diagnostics and therapeutics. You will be designing, creating, developing and characterising synthetic or human donor sourced, phage display libraries with a wide range of analysis techniques. You will have: PhD (or be near completion) in a Life science or another relevant subject. Have excellent skills in transfection, a range of PCR techniques, site directed mutagenesis, DNA library production and recombinant DNA technologies experience. Salary: Up to £32,000 depending on experience Immediate start Fantastic first role for a post PhD candidate

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  • Group Leader – Fermentation 10/29/2018 12:00:00 AM

    Salary: £0 Location: Saffron walden

    Group Leader – Fermentation- Cambridgeshire Based in Cambridge, my client is a specialist biopharmaceutical company, focusing on diagnosis and treatment of a wide range of diseases, including infections, autoimmune disorders and cancer. A fantastic opportunity has been developed for an experienced Group Lead in Fermentation. This role will contribute to the preclinical development of novel medicines and the successful candidate will be responsible for DOE, in-house fermentation, bacterial characterising and optimising their growth and providing support for upstream/ downstream method development and optimisation. You will have: • PhD in Microbiology, Bioprocess Engineering or another relevant subject, with a focus on fermentation and cell harvest or experience in equivalent closely-related discipline • 5 years post-doctoral industrial experience in a bioprocess development environment utilising fermentation technology • Experienced in using Design of Experiments (DOE) • Experienced in optimising biotech processes and methodologies • Ability to rigorously plan and accurately document research activities The following personal attributes are essential: • A high level of leadership and initiative. • A team worker with willingness to contribute flexibly as required • Excellent communication and interpersonal skills • Candidates must be legally entitled to work in the UK Competitive salary Excellent career opportunities

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  • Senior Viral Vector Scientist 10/23/2018 12:00:00 AM

    Salary: £46000 Location: London

    The Client My client, based in London, are specialists in helping Cell and Gene therapy companies translate early stage research into quality, commercially viable, scalable and investable therapies. With a team of over 120 Cell and Gene therapy experts and state-of-the-art development and viral vector labs, my client has ensured they remain a Centre of Excellence in this field. Purpose of Role: The purpose of this role is to provide expertise in the execution of viral vector industrialisation projects. The viral vector strategy will focus on the use of industrial bioprocessing techniques such as bioreactors and chromatography, to ensure supply of these critical materials for in vivo and ex vivo cell therapies. Key Accountabilities: Delivery of viral vector process and analytical development projects through technical oversight of project, working with the Lead Scientist on experimental design and execution. Particular focus upon downstream process operations, including unit operations from harvest to final fill Assist with costing of proposals for partners and support of BD function during new project scoping by providing technical support activities. Strong interaction with the Tech Transfer function and Project Managers to enable the development and tech transfer of viral vector processes. Strong Interaction with academic and industry based groups to provide engineering solutions for vector cell line development, upstream and downstream bioprocessing Generating manufacturing and development protocols in relation in vivo and ex vivo gene therapy products to support technology development and regulatory submissions Author GM Risk Assessments when requested and support GMSO. Maintain general laboratory cleanliness, Health and Safety and GXP standards, where appropriate Experience Experience of upstream and downstream bioprocessing of viral vectors including viral vector biology and cell line development. Experience or know how of working with GMP regulations to manufacture viral vectors, cell therapies or other biologics. Experience of cell culture of human and/or mammalian cell lines is essential. Experience in the development of analytical assays suitable for use as characterisation, QC release methods and in-process controls is desirable. Experience of tech transfer to/from commercial and research organisations Experience of viral vectors used in the ex vivo and in vivo modification of products is essential. Experience of working closely with BD and partners to plan, cost and secure projects. Experience in QMS is highly desirable. Experience in writing and carrying out GMP production protocols is desirable. Experience of delivering on agreed commercial objectives For more information please contact Robert Frame on: robert.frame@wearenorthpoint.co.uk or 0161 504 8058

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  • Technology Development Scientist 10/2/2018 12:00:00 AM

    Salary: £0 Location: Oxford

    I have an incredible opportunity to join a Teal organisation who are pioneering the latest and greatest Super-Resolution Fluorescent Microscopes. My client has made huge waves in the industry and were founded on the back of Nobel Prize winning research. They’re now looking to grow their company and have a number of exciting opportunities for those who are ready and capable of joining a multi-disciplinary team, working with autonomy and confidence. I am looking for an ambitious, organised and hardworking molecular biologists or biochemists to develop single-molecule applications - novel biochemical methods to work with my clients state-of-the-art microscopy system. You will be part of a nascent research activity, imagining, creating and following through on clever new ideas. You will be responsible for designing, performing and analysing new assays that use the microscope in clever ways to explore biological samples of interest. Having complete accountability day-to-day for setting up, organizing and performing experiments, as well as analysing, organising and reporting on the data produced and participating in team meetings, strategy discussions and journal clubs. If you want to join a team who are literally changing the way in which we see the world, this could be the opportunity for you. For more information and a confidential discussion, please contact me on: - Tel: 0161 923 8174 Email: kieran.whttaker@wearenorthpoint.co.uk

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  • Qualified Person 8/20/2018 12:00:00 AM

    Salary: £0 Location: Stevenage

    The Client My client, based in Stevenage, are specialists in helping Cell and Gene therapy companies translate early stage research into quality, commercially viable, scalable and investable therapies. With a team of over 120 Cell and Gene therapy experts and state-of-the-art development and viral vector labs, my client has ensured they remain a Centre of Excellence in this field. The Role The Qualified Person (QP) will participate in the translation of strategic direction into a Quality framework that defines, directs and governs the tactical application of GMP compliance for the Manufacturing Centre. In the first instance, this will be predominantly focused on developing and supporting the delivery of a fit for purpose Quality Management System and providing practical quality subject matter expertise to both CGT and collaborating residents (“Collaborators”). This activity will be required to support the initial grant of the facility MIA and MIA(IMP), and then to support on-going operations. The Manufacturing Centre hosts Collaborator manufacturing activities. You will perform batch certification for Collaborator manufacturing activities, as required, and act as a QP for the Manufacturing Centre. Responsibilities • Direct report to the Head of QA with close interaction with the Manufacturing Centre Management Team • Provide subject matter expertise in quality assurance, aseptic manufacturing and environmental microbiology to Manufacturing Centre staff and Collaborators • Ideally, act as Site Microbiologist, otherwise provide expert advice on Annex 1 requirements by approving the facility environmental monitoring, gowning and cleaning regimes. • Provide expert advice for microbiology changes and deviations and coach QC staff on microbiology as required (note: line management of the microbiology laboratories is not a part of this job specification) • Ensure the QMS is fit for purpose for a multi-purpose, multi-client facility, and maintain processes to ensure site compliance to the QMS • Maintain processes for batch certification for Collaborators and perform batch certification of ATMPs and or ATIMPs for Collaborators • Perform QP approval of Manufacturing Centre data (e.g. environmental monitoring data) to support certification by Collaborator QPs, Product Quality Reviews etc. • Develop and maintain QP to QP Agreements, as required, with Collaborator QPs • Represent the Manufacturing Centre as a QP, to external regulators, inspectors and Collaborators • Participate in the preparation and management of regulatory agency and client inspections, including co-hosting as required. Salary is negotiable on experience ---- For more information and a confidential discussion, please contact Kieran Whittaker on the below: - Tel: 0161 923 8174 Email: Kieran.Whittaker@wearenorthpoint.co.uk

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