Biotechnology

  • Scientist (Bioinformatics – Genome Editing) 6/11/2018 12:00:00 AM

    Salary: £38000 Location: Oxford

    My client, a leader in synthetic biology, is a specialised contract research organisation offering services to support the discovery, development and production of biologics, with a particular focus on viral vectors for gene therapy applications. A unifying theme across the portfolio is expertise in DNA design, expression system optimisation, cell line development and engineering of viral delivery systems. They are located within purpose-fitted laboratories at the Oxford Science Park, just South of Oxford. They are in a phase of rapid expansion and are seeking highly motivated and enthusiastic scientists and engineers to join the team and help facilitate the next stage of their development as a company. My client seeks an enthusiastic and self-starting bioinformatician to design, implement and evaluate novel software tools to support their genome editing group. In particular, the successful applicant will train machine learning models to predict the targeting patterns of CRISPR/Cas9 gRNAs. The successful applicant will join their interdisciplinary bioinformatics team, working alongside scientific programmers, infrastructure engineers, and web app developers to support both commercial and R&D projects. No prior experience of working with CRISPR/Cas9 is needed. Key Responsibilities + Work with the genome editing team and NGS specialists to develop a framework for reliably evaluating the targeting patterns of CRISPR/Cas9 gRNA libraries. + Apply state-of-the-art data science and statistical learning techniques to derive gRNA suitability/fitness rule-sets from the in-house CRISPR/Cas9 NGS datasets. + Engineer user-friendly software tools to facilitate CRISPR/Cas9 gRNA library design against new targets; work closely with the in-house software engineers to integrate interfaces for these into the web-based LIMS. + Stay up-to-date with new developments, technologies and methods in genome editing, and proactively seek out collaborations with their group leaders to develop and extend our intellectual property portfolio in this area. + Carry out any other duties commensurate with the grading of this post, as required. Salary is negotiable on experience.

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  • Validation Manager 6/11/2018 12:00:00 AM

    Salary: £65000 Location: OXFORD

    Validation Manager (permanent)- Oxford- Biotech- up to £65k Based in Oxfordshire, my client is a world leader in Gene and Cell Therapy technologies. Due to a fantastic period of growth they have an exciting opportunity for a motivated individual to join and lead the validation department as a Validation Manager. You will be responsible for acting as the subject matter expert and supporting the GMP manufacturing facilities by managing and coordinating all aspects of validation (equipment & facilities qualification and routine requalification activities, cleaning validation, computerised systems validation and process validation) and overseeing the Validation Team. Key skills and requirements: You will have: BSc in life sciences or another relevant subject Significant validation experience within a GMP environment Valid UK Driving License Significant team management experience. Proven problem-solving skills/diagnosing faults/resolving qualification issues. Competitive Salary Fantastic development opportunities Great Career progression

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  • Process Compliance Officer 6/6/2018 12:00:00 AM

    Salary: £40000 Location: OXFORD

    Process Compliance Officer Based in Oxfordshire, my client is a world leader in Gene and Cell Therapy technologies. Due to a fantastic period of growth they have an exciting opportunity for a motivated individual to join the manufacturing department in the role of Process Compliance Officer. As a Process Compliance Officer, you will work alongside the GMP Manufacturing teams to ensure the timely completion of batch related issues, as well as ensuring compliance with internal and external GMP requirements. Including leading investigations and root cause analysis into process and facility deviations, CAPAs and non-conformances with in a GMP, pharma/ Bio tech industry. You will have: Experience of working within a GMP manufacturing environment Experience with Manufacturing documentation such as SOPs, Deviations, Change Controls Risk Assessments and CAPAs Familiarity with Root Cause Analysis techniques and the ability to amalgamate and interpret complex data in an investigative capacity would be an advantage Competitive salary Excellent benefits

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  • Innovation Officer 6/5/2018 12:00:00 AM

    Salary: £45000 Location: Cambridge

    Based in Cambridgeshire my client is a leading biotech company specialising in Gene editing platform technology. Due to expansion they are currently looking to take on an Innovations Officer to join a diverse and energetic team. You will be responsible for liaising with the company on matters of technology transfer, IP and Patent searches. You must be approachable, friendly and have a confident manner. Ideally you will have; + PhD in Life Sciences subject (i.e Biology, Genetics, Virology, Immunology, bioinformatics etc) + Knowledge of technology transfer and Patent Searches + Basic understanding of IP The company offers great career progression and a starting salary around the £45k mark.

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  • Senior Analytical Scientist in Process, Research and Development 6/5/2018 12:00:00 AM

    Salary: £42000 Location: Oxford

    Our client is a leading biopharmaceuticals organisation based from state-of-the-art offices in Oxford. Having rapidly expanded over the course of the last 3 years to over 300 employees, they are currently recruiting a wide range of biotechnology based positions. The company are at the forefront of the gene and cell therapy sector, having built a novel drug development platform which they leverage to develop products both in-house and with partners. Their proprietary portfolio of products include a lead product for Parkinson’s disease. With preparations completed for this to move into the clinic, they are in active discussions with a number of third parties to potentially out-licence the product, thereby sharing the costs and the risks whilst retaining an interest in the value of the product as it progresses. Other products at development stage include a gene-based therapies for corneal graft rejection and cancer. The company have a very respected name in the industry, and offer potential candidates a strong career path, generous financial renumeration, and a caring yet focussed environment in which to flourish. We are helping them to recruit a senior analytical scientist for their process, research and development department. Candidates should have experience with the following; + Bsc in Life-sciences or biotechnology related subject. + Strong aseptic techniques + Knowledge of general cellular, and molecular biology techniques + Practical experience of a range of bio-process analytical techniques such as cell based assays, FACS, nucleic acid extractions qPCR, SDS< Western blot, ELISA + Strong written and verbal skills Salaries for the roles are expected to be in the 38-42k range.

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  • Validation Specialist 6/5/2018 12:00:00 AM

    Salary: £45000 Location: Oxford

    I am currently recruiting for a Validation Specialist to join a world-renowned biopharmaceutical company; this company specialises in developing innovative gene-based medicine and therapeutic vaccines. This exciting about has come about due to the year-on-year growth and are now in a position to bring a talented Validation Specialist to join the team in their Oxford based site. This person will support GMP manufacturing and laboratory facilities by ensuring all aspects of validation (manufacturing & laboratory equipment, facilities and utilities qualification and routine requalification activities, cleaning validation, computerised systems validation and process validation) are complete and up to date. The Validation Team also represent the business in customer audits and regulatory inspections to demonstrate compliant systems. + Ensure compliance with regulatory requirements and Quality Management System by supporting/assisting Validation Manager in performing and managing qualification and validation studies of GxP critical systems, equipment and processes. + Generate validation documentation including master plans, validation assessments and test protocols; execute qualification/validation protocols/studies + Ensure Validation Department provides timely, appropriate and expert advice on qualification and validation issues to Manufacturing, QC/QA & Engineering and other company functions as required + Supporting the validation of equipment, facilities, utilities and processes in accordance with GMP requirements and a lifecycle approach in coordination with multi-functional Validation + Represent the Validation Department during client audits and regulatory inspections ***What the Validation Specialist needs*** + Demonstrable validation experience in a biopharmaceutical, pharmaceutical or related industry including Manufacturing/Laboratory Equipment, Facilities & Utilities Qualification (URS, DQ, IQ, OQ & PQ) + Broad knowledge of biopharmaceutical and pharmaceutical industry regulations and guidelines including GMP, GDP, GLP, GEP + Experience of aseptic processing and cleanrooms highly desirable + Computer Systems Validation (CSV) would be advantageous + Educated to degree level in Science (Biological) ***What the Validation Specialist will get*** + Competitive salary + excellent benefits + Work in a fantastic state-of-the-art facility + Lots of training and development opportunities If this sounds like the perfect role for you, then please get in touch today!

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  • Team Leader in Library Design 6/5/2018 12:00:00 AM

    Salary: £55000 Location: Saffron walden

    Team Leader - Library Design, Cambs, up to £60k + Management role at well-established Biotech + Antibody libraries + Interviews immediately My client are a biotechnology company located in Cambridgeshire specialising in providing protein engineering services for the discovery, identification and design of new peptide, protein and antibody compounds. We are seeking a confident Team Leader to head up an NGS platform to support lead discovery projects and line manage a small team. Youll need to evidence: + PhD / equivalent and line management + Next Generation Sequencing (NGS) for library manufacturing + Lead discovery using display technologies

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  • Patent Officer 6/4/2018 12:00:00 AM

    Salary: £33000 Location: Oxford

    Based in Oxford our client is a leader in synthetic biology and are a specialised contract research organisation offering services to support the discovery, development and production of biologics, with a particular focus on viral vectors for gene therapy applications. They are recruiting for a large number of positions at present and are interested in qualified candidates to fill their patent officer role. The main duties of the role are as follows; + To enable the company to develop a cost-effective patent portfolio and to maximise opportunities to fund the company’s product and services development road-map via grant funding + Taking over work initially performed in other areas of the business and liaising extensively with the company’s Research and Development employees and the CFO + Identification of opportunities for new patent or grant applications + Drafting and filing applications for grants, patents, trademarks etc. + Collating and recording cost, labour time and other relevant data + Prior art searching + Patent renewal management Candidate should have; + Experience in a similar role dealing with Patent administration + Strong communication and organisational skills + A qualification in Grant or Patent administration is desirable but not essential Salaries for the role are competitive and are expected to be around the 28-33k range.

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  • Principal Product Development Scientist 5/29/2018 12:00:00 AM

    Salary: £50000 Location: WELWYN GARDEN CITY

    Principal Product Development Scientist My client is an award-winning clean technology company that has industrialised the process of recycling biomaterials for industry use. Due to continued development they are looking to take on an enthusiastic, dedicated and hands-on, Principal Product Development Scientist to lead a small team of scientists, Creating new flavours & fragrances and functional oil-based bio-chemical products from waste bio-materials. You will have: A MSc or PhD in Chemistry, food science or a related, relevant discipline. At least 7 years industry experience in New Product Development within the flavour & fragrance, food & beverage or other relevant industry sector, with experience of formulation equipment and processing Experience of presenting to large audiences and networking at relevant external events Experience of developing, coaching and leading other scientists and work colleagues Salary- Dependant on experience- up to £50,000 Great development opportunities The company’s head office is based in central London, with their scientific facility-based Welwyn Garden City’s, BioPark. The Principal Product Development Scientist will be based in the laboratory at the BioPark but it wouldn’t be unusual to be travelling across locations.

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  • Group Leader within AAV Vectors 5/23/2018 12:00:00 AM

    Salary: £60000 Location: Oxford

    Based in Oxford our client is a leader in synthetic biology and are a specialised contract research organisation offering services to support the discovery, development and production of biologics, with a particular focus on viral vectors for gene therapy applications. They are recruiting for a large number of positions at present and are interested in qualified candidates to fill their group leader role within the AAV vectors division. The Group Leader will be involved in a range of internal platform development and commercial projects, predominantly focused on establishing novel AAV vectors, stable viral packaging cell lines/bioproduction systems, and running a commercial batch production function through a sub-team. The company have a number of on-going programmes and collaborations in this area, and multiple government supported grant awards, which the recipient will contribute towards. Prior experience in engineering AAV vectors is essential, as is a detailed knowledge of AAV vector biology, production and characterisation methodologies. Group Leaders are expected to take a scientific and technical leadership role, while providing support and training to Scientists and technicians working in the group. The position will involve extensive interaction with both internal and external stakeholders, and the ability to show commitment to scientific development and innovation are considered essential. Candidate should have experience in the following; + PhD/DPhil in relevant discipline, with significant experience (>4 years) + Experience working in a commercial/industry environment is preferred but not essential + Demonstrated people management ability, through supervision and development of junior colleagues + Strong network within AAV research and/or commercial arena + Extensive track record of handling a range of adherent and suspension mammalian cell lines + High-level knowledge and experience of viral vector engineering, production and characterisation, with a focus on AAV + Good experience with analytical techniques including flow cytometry/FACS, qPCR, ELISA, HPLC Salaries for the role are expected to be in the 50-65k range.

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