Pharmaceuticals

  • Senior Scientist Microbiology 8/15/2018 12:00:00 AM

    Salary: £0 Location: Aberdeen

    My client is a leading pharmaceutical company focusing on developing live biotherapeutic products from the human gut microbiome. So far, my client has two clinical stage programmes in IBS and IBD as well as a strong pipeline of pre-clinical programmes in autoimmunity, inflammation, oncology and CNS disease. Due to recent expansion, my client is looking for a Senior Microbiology Scientist to help make scientific observations, maintain detailed workbooks/documentation and ensure all documentation fulfils generally accepted professional/industry standards. The senior scientist will be expected to propose new screening strategies and introduce and validate new screening approaches/methods ensuring they are current and compliant with industry standards and regulations. Essential Qualifications: PhD Degree in Microbiology with expertise in human gut biology or immunology. At least 5 years of post doc experience or 5 years’ experience working in an industrial en­vironment in a similar role. Essential experience: Competency with microbiology techniques especially in the cultivation of anaerobic microbes. Competency with cell culture techniques. Competency in a range of screening assays relevant to host-microbe interactions. Expertise in running anaerobic bioreactors and in the techniques used to monitor microbial community composition. Experience with biofilm-related techniques- total biomass, viability and susceptibility testing. Experience in immunological assays Key Areas of Responsibility Running assay development and validation for the discovery and characterisation of LBPs, in particular where gut cells and bacteria are involved. Introduce and validate new screening approaches/methods ensuring they are current and compliant with industry standards and regulations. Report results to the Team Leader and senior members of the team. Perform laboratory techniques and protocols according to SOPs and provide technical support to the Discovery I Micro team. Interact and liase with the Discovery I Host team. Keep accurate and detailed records of data. Attend and contribute to research group meetings and external event.

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  • Control and Instrumentation Engineer 8/13/2018 12:00:00 AM

    Salary: £29355 Location: Salisbury

    My client is a leading developer and manufacturer of life saving pharmaceutical therapeutics and vaccines. The client performs a range of breakthrough production, quality and development roles within the pharmaceutical production process. The client is looking for an effective communicator who has GMP experience and can work to a high standard. The candidate would ideally need to be highly organised as well as the ability to work within a team. Pharmaceutical industry experience is desirable. MAIN DUTIES AND RESPONSIBILITIES •Responsible for the troubleshooting and liaising with Engineering and maintenance technicians to establish route cause, develop and manage appropriate corrective action plans and report. •Instigate and manage improvement projects, in particular those relating to control and automation systems. This shall include delivery of software improvements in full compliance with GAMP. •Maintain compliance of the Engineering owned Data Acquisition Systems including ensuring suitable provision and execution of GMP compliant operational and administration policies and procedures. •Manage the contracted specialist support in delivery of the Engineering Service in support of Control and Automation Systems. •Coordinate the delivery of the Preventive Maintenance and Asset Care Plans with the Instrumentation Manager and maintenance scheduling resources. •Represent the company as a Engineering subject matter expert for Control and Automation systems in Regulatory Audits and in the delivery of Capital projects.

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  • Manufacturing Development Scientist 8/8/2018 12:00:00 AM

    Salary: £35000 Location: Hampton

    My Client has established a high quality DNA manufacturing platform technology, using an in vitro enzymatic process and has a role available for an experienced process development scientist in its expanding Manufacturing/CMC Development Group. The successful applicant will play an important role in product specific development of dbDNATM manufacturing processes. This will involve working in a team focussed on establishing critical parameters and controls using design of experiments approach; industrial scale up and technical transfer of processes to third parties/GMP manufacturing organisations. This new role presents an exciting opportunity, with the successful applicant being involved in a range of process development projects. Essential: • A PhD level qualification in Biochemistry / Protein chemistry / Molecular Biology or equivalent industrial experience. • In addition, experience of CMC/process development in a pharmaceutical setting?. • Familiarity with standard bioprocessing techniques, such as chromatographic and filtration methods of separation. • Familiarity with standard Molecular Biology techniques such as cloning, PCR, mutagenesis and in related specialised DNA characterisation techniques. • Experience in keeping accurate and thorough records of laboratory experiments. In addition, experience of writing technical reports to a standard suitable for submission to regulatory authorities. • Applicants must be reliable, enthusiastic and self-motivated as well as having excellent communication skills and an ability to learn new techniques. • The ability to work well in a team environment and balance workload demands is vital.

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  • Research Scientist (Microbiology) 8/7/2018 12:00:00 AM

    Salary: £34000 Location: Aberdeen

    My client is a leading pharmaceutical company focusing on developing live biotherapeutic products from the human gut microbiome. So far, my client has two clinical stage programmes in IBS and IBD as well as a strong pipeline of pre-clinical programmes in autoimmunity, inflammation, oncology and CNS disease. Due to recent expansion, my client is looking for a Research Microbiology Scientist to perform testing required to support the core research and development of the strain library to help identify candidate live bio-therapeutic products capable of modulating host-microbe interactions. Alongside this you will also make scientific observations, maintain detailed workbooks/documentation and ensure all documentation fulfils generally accepted professional/industry standards. Essential Qualifications: PhD Degree in Microbiology, biomedical sciences or a least 5 years experience working in industry. Essential experience: Competency with microbiology techniques especially in the cultivation of anaerobic microbes. Competency with cell culture techniques. Competency in a range of screening assays relevant to host-microbe interactions. Expertise in HPLC; extraction, detection and quantification of small molecules. Key Areas of Responsibility Running assay development and validation for the discovery and characterisation of LBPs, in particular where gut cells and bacteria are involved. Introduce and validate new screening approaches/methods ensuring they are current and compliant with industry standards and regulations. Report results to the Team Leader and senior members of the team. Perform laboratory techniques and protocols according to SOPs and provide technical support to the Discovery I Micro team. Interact and liase with the Discovery I Host team. Keep accurate and detailed records of data. Attend and contribute to research group meetings and external event.

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  • Research Scientist- (Discovery II Host Team) 8/7/2018 12:00:00 AM

    Salary: £34000 Location: Aberdeen

    Based in Aberdeen, my client a pharmaceutical company focussed on developing several biotherapeutics based on the human gut microbiome. Due to continued growth they are looking for a Scientist to join their discovery team. The primary focus of the team is to investigate the mechanisms behind the host-microbe interactions of preclinical candidates. You should be Proficienct in running a variety of cellular and molecular techniques. The post-holder will also be responsible for writing reports and SOPs, contributing to writing papers, present at internal and external meetings. Ideal candidates will have most of the following; + PhD in molecular biology, biomedical sciences, or other science-related discipline or HNC with a minimum of 5 years industry experience. + Experience in immunology + Competent in designing and developing cell-based assays to investigate the MoA of LBP candidates + Competent with isolation and culture of primary cells from tissue samples (e.g. gut, spleen, lymph nodes) or human samples (e.g. blood) + Proven expertise in single-cell analysis techniques (e.g. multiparameter flow cytometry) Competent in assay development, cell culture techniques and variety of molecular laboratory techniques, including qPCR or flow cytometry or imaging techniques. Salary up to £34,000 depending on experience.

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  • Research Scientist (Discovery I (Host) Team) 8/7/2018 12:00:00 AM

    Salary: £34000 Location: Aberdeen

    Based in Northern Scotland, my client is a world leader in developing therapeutics from the human gut microbiome for the prevention, treatment or cure of disease; specifically, autoimmunity, inflammation, oncology and CNS disease. Due to continued growth they are looking for a Scientist to join their Discovery I Host team. The primary focus of the team is to perform high-throughput screening assays investigating host-microbe interactions for the identification of new LBPs in different therapeutic areas. You will need to be Proficient in running a variety of cellular and molecular techniques are required along with independent and flexible working. You will also be responsible for writing reports, SOPs, contributing to writing papers and presenting at internal and external meetings. You will need: PhD in molecular biology, biomedical sciences, or other science-related discipline or HNC with a minimum of 5 years industry experience. Experience in gut biology and/or mucosal immunology Competent in assay development, cell culture techniques and variety of molecular laboratory techniques, including qPCR or flow cytometry or imaging techniques. Salary- up to £34,000 (dep on experience). Fantastic development opportunities Great Benefits Excellent working environment

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  • Equipment Validation Manager 8/1/2018 12:00:00 AM

    Salary: £0 Location: Salisbury

    QA Compliance Officer - Audit The Client My client is a fast-growing biopharmaceuticals company based in the South-West of England. Experts in developmental production and the bringing to market of biologicals, my client have decades of experience in production, characterisation, process and analytical validation of life saving biopharmaceuticals, including the Anthrax Vaccine. The Role Taking on the mantle of Equipment Validation Manager will see you take the helm of validation activities for Equipment and Systems. You will be responsible for both Permanent and Contractor resources as well as project meetings, review of technical documents and ensuring strict compliance to GMP regulatory requirements. Responsibilities • Coordinate and manage the timely delivery of validation activities • Review and approve validation documentation • Line management of both permanent and contractor resources • Ensure Validation procedures and activities are aligned with current GMP regulatory Requirements ----- Are you prepared to begin a new chapter in your career? If so, this could be the role for you! For more information and a confidential discussion, please contact Kieran Whittaker on: - Tel: - 0161 923 8174 Email: - Kieran.whittaker@wearenorthpoint.co.uk Salary is negotiable on experience

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  • QA Compliance Officer - Audit 7/30/2018 12:00:00 AM

    Salary: £0 Location: Salisbury

    The Client My client is a fast-growing biopharmaceuticals company based in the South-West of England. Experts in developmental production and the bringing to market of biologicals, my client have decades of experience in production, characterisation, process and analytical validation of life saving biopharmaceuticals, including the Anthrax Vaccine. The Role Taking on the mantle of QA Compliance Officer - Audit You will be charged with formulating proposals for and provide active management of operational projects with responsibility for ensuring all aspects of project delivery for both the company and its customers. Responsibilities • To organise, plan and perform internal and external (supplier) audits, to follow up open audit reports and conduct reviews of audit responses in order to close out audit reports • To ensure supplier questionnaires are satisfactorily completed by key manufacturers and suppliers in a timely fashion. • To liaise with suppliers to obtain relevant information for their approval to provide key materials and services (incl. processing, BSE/TSE) • To approve GMP Monographs to ensure that suppliers are appropriately approved and BSE/TSE certificates are satisfactory. • To produce Quality Technical Agreements for the supply of and services from critical suppliers • To initiate and progress Supplier Complaints to closure. • To update the supplier monitoring database and associated spread sheets used for tracking. • To assist with the QA overview of manufacturing and testing areas. • To provide KPI reports measuring the performance of the systems and the team. • To undertake relevant training. • To undertake work in accordance with the Health and Safety policies and procedures and to work within any Quality Systems that are applicable to the site. • To comply with policies and procedures ----- Are you prepared to begin a new chapter in your career? If so, this could be the role for you! For more information and a confidential discussion, please contact Kieran Whittaker on: - Tel: - 0161 923 8174 Email: - Kieran.whittaker@wearenorthpoint.co.uk Salary is negotiable on experience

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  • Programme Scientist 7/25/2018 12:00:00 AM

    Salary: £40000 Location: Aberdeen

    My client is a leading pharmaceutical company focusing on developing live biotherapeutic products from the human gut microbiome. So far, my client has two clinical stage programmes in IBS and IBD as well as a strong pipeline of pre-clinical programmes in autoimmunity, inflammation, oncology and CNS disease. Due to recent expansion, my client is looking for a programme scientist to help provide subject matter expertise to help bridge the gap between pre-clinical to regulatory by providing scientific support to the manufacturing, clinical and regulatory teams. Report writing, and presentation skills play a key part with this role as there will be meetings held with numerous stakeholders related to the business. Experience / Qualifications Required • Bachelor’s degree in microbiology, biological sciences or related discipline • At least 2 years’ experience working in biological sciences or on microbiome derived products • Expertise in scientific programmes from preclinical to product development • Excellent report writing skills • Excellent communication skills and ability to work well within a team Key Areas of Responsibility • Provide scientific support to the manufacturing, clinical and regulatory teams, bridging the gap between pre-clinical to regulatory in providing scientific knowledge of the product; • Understand the needs of regulatory, clinical, manufacturing and research regarding candidate strains to co-ordinate activities between the departments; • Support the drafting of regulatory documents with scientific input pertaining to the candidate strain(s) such as Investigator’s Brochure and IMPD with the team; • Provide scientific knowledge regarding the candidate strain(s) at key meetings, Scientific Advice meetings with the regulators, meetings with clinical CRO’s, clinical Site Initiation Visits; • Provide scientific expertise in product development activities, such as antibiotic resistance testing, media, bacteria specific knowledge, preclinical studies; • Collection, analysis and presentation of scientific information pertaining to the products;

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  • Senior Lead Formulation Scientist 7/19/2018 12:00:00 AM

    Salary: £40000 Location: Nottingham

    My client is a contract development and manufacturing organisation (CDMO) specialising in advanced characterisation, Intellectual Property consulting, formulation development, analytical services and clinical manufacturing. Due to continued expansion they are looking for a Senior Lead Formulation Scientist to join a diverse and dynamic team, in a fast-paced environment, providing technical excellence in the development of solid-oral/topical based dosage formats. You will need to demonstrate an in-depth knowledge of techniques, instrumentation and interpretation of scientific data within cGMP guidelines, as well as coaching and mentoring junior staff. You will need: BSc in Pharmaceutical sciences, Chemistry or another relevant subject. GMP Industry experience is a must Experience in formulating a range of Pharmaceutical dosage forms, in particular solid oral dose forms. Experienced in using a range of Pharmaceutical Processing equipment, in particular wet and dry granulation, spray drying, tabletting and coating. Salary- Up to £40,000 depending on experience Fantastic career oppurtunities • Contributory Pension scheme • 25 days holiday - plus bank holidays • Death in service • Healthcare provision • Health Shield • Free parking • Childcare vouchers • Perk Box • Learning & Development opportunities

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